Gilcher R O
Vox Sang. 1986;51 Suppl 1:35-9. doi: 10.1111/j.1423-0410.1986.tb01992.x.
Manual plasmapheresis is done worldwide on both paid donors, and to a much smaller extent on volunteer donors in order to generate source plasma to be fractionated into albumin, clotting factor concentrates, and gamma globulin. Automated technology has now been developed utilizing both centrifugal, and membrane separation devices (Haemonetics PCS centrifugal, Organon Teknika PLASMAPUR-membrane, HemaScience Autopheresis-C-spinning membrane) and is much faster and safer than the manual techniques with regard to the donor. The single biggest difficulty with automated technology is the high cost of the software, making the cost of producing source plasma by this type of technology, in general, not cost efficient at this time. However, fresh frozen plasma can be generated by this technology, which is cost efficient and provides a single donor source of 500 ml plasma, making the product safer for those patients that do require fresh frozen plasma by reducing the number of donor exposures to the patient.
在全球范围内，人工血浆分离术应用于有偿献血者，在较小程度上也应用于志愿献血者，目的是获取原料血浆，以便将其分离成白蛋白、凝血因子浓缩物和丙种球蛋白。目前已开发出自动化技术，该技术利用离心和膜分离装置（Haemonetics PCS离心机、Organon Teknika PLASMAPUR膜式、HemaScience Autopheresis-C旋转膜式），就献血者而言，其速度比人工技术快得多且更安全。自动化技术的最大难题在于软件成本高昂，总体而言，目前使用这类技术生产原料血浆的成本效益不高。不过，该技术能够生成新鲜冰冻血浆，这种血浆具有成本效益，并且提供500毫升单一献血者来源的血浆，通过减少献血者与患者的接触次数，使该产品对那些确实需要新鲜冰冻血浆的患者来说更安全。
