Lv Dong, Guo Yanfu, Zhang Li, Li Xia, Li Guangping
Department of Cardiology, Tianjin Key Laboratory of Lonic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Department of Cardiology, Beijing Renhe Hospital, Beijing, China.
Front Cardiovasc Med. 2023 Jun 15;10:1196348. doi: 10.3389/fcvm.2023.1196348. eCollection 2023.
Serum miR-183-5p levels are associated with carotid atherosclerosis, while less is known about the relationship between circulating miR-183-5p levels and stable coronary artery disease (CAD).
In this cross-sectional study, consecutive patients with chest pain who underwent coronary angiograms from January 2022 to March 2022 at our center were enrolled. Those presenting acute coronary syndrome or had a prior CAD were excluded. Clinical presentations, laboratory parameters, and angiographic findings were collected. Serum miR-183-5p levels were measured using quantitative real-time polymerase chain reaction. CAD severity was displayed as the number of diseased vessels and further evaluated by the Gensini score system.
Overall, 135 patients (median age, 62.0 years; male, 52.6%) were included in the present study. Stable CAD was identified in 85.2% of the study population, with 45.9% having 1-vessel disease, 21.5% having 2-vessel disease, and 17.8% having 3-vessel or left main disease. Serum miR-183-5p levels were significantly increased in CAD patients with different severities than non-CAD patients (all adjusted < 0.05). Serum miR-183-5p levels increased as tertiles of the Gensini score progressed (all adjusted < 0.05). Importantly, serum miR-183-5p levels could predict the presence of CAD and 3-vessel or left main disease in the receiver operating characteristic curve analysis (both < 0.01), and also in multivariate analysis adjusting for age, sex, body mass index, diabetes, hypersensitive-C-reactive protein (both < 0.05).
Serum miR-183-5p levels are independently and positively correlated with CAD presence and severity.
血清miR-183-5p水平与颈动脉粥样硬化有关，而关于循环miR-183-5p水平与稳定型冠状动脉疾病（CAD）之间的关系，人们了解较少。
在这项横断面研究中，纳入了2022年1月至2022年3月在本中心接受冠状动脉造影的连续胸痛患者。排除那些表现为急性冠状动脉综合征或既往有CAD的患者。收集临床表现、实验室参数和血管造影结果。使用定量实时聚合酶链反应测量血清miR-183-5p水平。CAD严重程度以病变血管数量表示，并通过Gensini评分系统进一步评估。
总体而言，本研究纳入了135例患者（中位年龄62.0岁；男性占52.6%）。研究人群中85.2%被诊断为稳定型CAD，其中45.9%为单支血管病变，21.5%为双支血管病变，17.8%为三支血管或左主干病变。与非CAD患者相比，不同严重程度的CAD患者血清miR-183-5p水平显著升高（所有校正后<0.05）。血清miR-183-5p水平随着Gensini评分三分位数的升高而升高（所有校正后<0.05）。重要的是，在受试者工作特征曲线分析中，血清miR-183-5p水平可预测CAD以及三支血管或左主干病变的存在（两者均<0.01），在调整年龄、性别、体重指数、糖尿病、超敏C反应蛋白的多变量分析中也是如此（两者均<0.05）。
血清miR-183-5p水平与CAD的存在和严重程度独立且呈正相关。
