Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, China.
Theranostics. 2022 Jul 4;12(11):5103-5124. doi: 10.7150/thno.74548. eCollection 2022.
Osteoarthritis (OA) is a common joint disease with a high disability rate. In addition, OA not only causes great physiological and psychological harm to patients, but also puts great pressure on the social healthcare system. Pathologically, the disintegration of cartilage and the lesions of subchondral bone are related to OA. Currently, tissue engineering, which is expected to overcome the defects of existing treatment methods, had a lot of research in the field of cartilage/osteochondral repair. Silk fibroin (SF), as a natural macromolecular material with good biocompatibility, unique mechanical properties, excellent processability and degradability, holds great potential in the field of tissue engineering. Nowadays, SF had been prepared into various materials to adapt to the demands of cartilage/osteochondral repair. SF-based biomaterials can also be functionally modified to enhance repair performance further. In this review, the preparation methods, types, structures, mechanical properties, and functional modifications of SF-based biomaterials used for cartilage/osteochondral repair are summarized and discussed. We hope that this review will provide a reference for the design and development of SF-based biomaterials in cartilage/osteochondral repair field.
骨关节炎（OA）是一种常见的关节疾病，致残率高。此外，OA 不仅给患者造成极大的生理和心理伤害，也给社会医疗保健系统带来巨大压力。从病理上看，软骨的崩解和软骨下骨的病变与 OA 有关。目前，组织工程学有望克服现有治疗方法的缺陷，在软骨/骨软骨修复领域进行了大量研究。丝素蛋白（SF）作为一种具有良好生物相容性、独特力学性能、优异加工性和可降解性的天然高分子材料，在组织工程领域具有巨大的潜力。如今，SF 已被制备成各种材料，以适应软骨/骨软骨修复的需求。SF 基生物材料也可以进行功能修饰，以进一步提高修复性能。本文综述了用于软骨/骨软骨修复的 SF 基生物材料的制备方法、类型、结构、力学性能和功能修饰，希望为软骨/骨软骨修复领域 SF 基生物材料的设计和开发提供参考。
