Rupa Sharmin Akther, Patwary Md Abdul Majed, Matin Mohammed Mahbubul, Ghann William Emmanuel, Uddin Jamal, Kazi Mohsin
Department of Chemistry, Comilla University, Cumilla 3506, Bangladesh.
Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh.
Toxicol Res (Camb). 2023 May 30;12(3):355-368. doi: 10.1093/toxres/tfad039. eCollection 2023 Jun.
The nature of the binding of mercurials (organic and inorganic) and their subsequent transformations in biological systems is a matter of great debate as several different hypotheses have been proposed and none of them has been conclusively proven to explain the characteristics of Hg binding with the proteins. Thus, the chemical nature of Hg-protein binding through the possible transportation mechanism in living tissues is critically reviewed herein. Emphasis is given to the process of transportation, and binding of Hg species with selenol-containing biomolecules that are appealing for toxicological studies as well as the advancement of environmental and biological research.
汞化合物（有机汞和无机汞）的结合性质及其在生物系统中的后续转化是一个备受争议的问题，因为已经提出了几种不同的假设，但没有一种被确凿证明能够解释汞与蛋白质结合的特性。因此，本文对通过活组织中可能的转运机制实现的汞 - 蛋白质结合的化学性质进行了批判性综述。重点关注汞物种的转运过程以及与含硒醇生物分子的结合，这对于毒理学研究以及环境和生物学研究的进展具有重要意义。
