Sutedja Eva Krishna, Elgianda Ghabrina Saraswati, Sutedja Endang, Ruchiatan Kartika
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
Int Med Case Rep J. 2023 Jun 26;16:391-396. doi: 10.2147/IMCRJ.S409840. eCollection 2023.
Basal cell carcinoma (BCC) is the most common skin malignancy, consisting of cells in the basal layer epidermis and its appendix. Superficial BCC is the second most common BCC subtype with a predilection on the trunk including the waist and can be treated with cryoimmunotherapy, a combination of cryotherapy and imiquimod cream. Herein, we report a case of superficial BCC in a 60-year-old woman which was triggered by short-wave diathermic (SWD) therapy on the waist one year previously. Superficial BCC was diagnosed based on clinical symptoms, a dermoscopy, and histopathology. The erythematous and hyperpigmented plaque on the waist had well-defined edges and bled easily. There were pseudopods, a blue-grey ovoid nest, haemorrhagic ulceration, and a deeply pigmented border with basaloid cells in the basal layer of the epidermis and palisade cells at the edges. The patient was treated with cryoimmunotherapy consisting of two cycles of a 30-second freeze time and a 5 mm margin, then two weeks later, 5% imiquimod cream was applied to the skin for five consecutive nights, followed by two days off for six cycles (six weeks). Follow-up at three months revealed clinical improvement with reduced lesion size, confirming that cryoimmunotherapy is an effective treatment for the management of superficial BCC with mild side effects.
基底细胞癌（BCC）是最常见的皮肤恶性肿瘤，由表皮基底层及其附属器中的细胞组成。浅表性基底细胞癌是基底细胞癌的第二常见亚型，好发于包括腰部在内的躯干，可采用冷冻免疫疗法治疗，即冷冻疗法与咪喹莫特乳膏联合使用。在此，我们报告一例60岁女性的浅表性基底细胞癌病例，该病例由一年前腰部的短波透热疗法（SWD）引发。根据临床症状、皮肤镜检查和组织病理学诊断为浅表性基底细胞癌。腰部的红斑和色素沉着斑边界清晰，容易出血。有伪足、蓝灰色卵圆形巢、出血性溃疡以及在表皮基底层有深色素沉着边界和基底样细胞，边缘有栅栏状细胞。患者接受了冷冻免疫疗法，包括两个周期，每次冷冻时间为30秒，边缘为5毫米，两周后，连续五个晚上在皮肤上涂抹5%咪喹莫特乳膏，然后休息两天，共六个周期（六周）。三个月后的随访显示临床症状改善，病变大小减小，证实冷冻免疫疗法是治疗浅表性基底细胞癌的有效方法，且副作用轻微。
