Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States.
Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States.
Front Immunol. 2023 Jun 19;14:1195871. doi: 10.3389/fimmu.2023.1195871. eCollection 2023.
The SARS-CoV-2 pandemic and the COVID-19 disease have affected everyone globally, leading to one of recorded history's most significant research surges. As our knowledge evolves, our approaches to the virus and treatments must also evolve. The evaluation of future research approaches to SARS-CoV-2 will necessitate reviewing the host immune response and viral antagonism of that response. This review provides an overview of the current knowledge on SARS-CoV-2 by summarizing the virus and human response. The focuses are on the viral genome, replication cycle, host immune activation, response, signaling, and antagonism. To effectively fight the pandemic, efforts must focus on the current state of research to help develop treatments and prepare for future outbreaks.
SARS-CoV-2 大流行和 COVID-19 疾病已在全球范围内影响到每个人，导致了有记录以来规模最大的研究热潮之一。随着我们知识的不断发展，我们对病毒的处理方法和治疗方法也必须随之发展。评估未来针对 SARS-CoV-2 的研究方法需要对宿主免疫反应和病毒对该反应的拮抗作用进行审查。这篇综述通过总结病毒和人类反应，提供了 SARS-CoV-2 的最新知识概述。重点介绍了病毒基因组、复制周期、宿主免疫激活、反应、信号转导和拮抗作用。为了有效抗击大流行，必须集中精力研究当前的研究状况，以帮助开发治疗方法并为未来的疫情爆发做好准备。
