Department of Chemistry, Isabella Thoburn College, Lucknow, UP 226007, India.
Department of Chemistry, Integral University, Lucknow, UP 226026, India.
J Trace Elem Med Biol. 2023 Sep;79:127245. doi: 10.1016/j.jtemb.2023.127245. Epub 2023 Jun 21.
Many transition metal complexes have been explored for their therapeutic properties after the discovery of cisplatin. Schiff bases have an efficient complexation tendency with the transition metals and several medicinal properties have been reported. However, fewer studies have reported the medicinal utility of vanadium and its Schiff base complexes. This paper provides a comprehensive overview of vanadium complexes with Schiff bases along with their mechanistic insight. Vanadium complexes in + 4 and + 5 oxidation states have exhibited well-defined geometry and found to be thermodynamically stable. The studies have reported the G0/G1 phase cell cycle arrest and decreased delta psi m, inducing mitochondrial membrane depolarization in cancer cell lines along with the alterations in the metabolism of the cancer cells upon dosing with the vanadium complexes. Cancer cell invasion and growth are also found to be markedly reduced by peroxo complexes of vanadium. The studies included in the review paper have been taken from leading indexing databases and focus was laid on recent reports in literature. The biological potential of vanadium complexes of Schiff bases opens new horizons for future interdisciplinary studies and investigation focussed on understanding the biochemistry of these complexes, along with designing new complexes which have better bioavailability, solubility and low or non-toxicity.
顺铂发现后，许多过渡金属配合物因其治疗特性而被探索。席夫碱与过渡金属具有有效的络合倾向，并已报道了几种药用特性。然而，较少的研究报道了钒及其席夫碱配合物的药用用途。本文全面概述了具有席夫碱的钒配合物及其作用机制。+4 和 +5 氧化态的钒配合物具有明确的几何形状，被发现热力学稳定。研究报告称，钒配合物在癌细胞系中诱导 G0/G1 期细胞周期停滞和 delta psi m 降低，导致线粒体膜去极化，同时改变癌细胞的代谢。钒的过氧配合物也显著降低了癌细胞的侵袭和生长。综述中包含的研究来自主要索引数据库，并侧重于文献中的最新报道。席夫碱钒配合物的生物学潜力为未来跨学科研究和关注理解这些配合物的生物化学以及设计具有更好生物利用度、溶解度和低毒性或非毒性的新型配合物开辟了新的前景。
