State Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China.
Anal Chem. 2023 Jul 18;95(28):10465-10475. doi: 10.1021/acs.analchem.3c00543. Epub 2023 Jul 6.
Nanopore sensing technology is an emerging analysis method with the advantages of simple operation, high sensitivity, fast output and being label free, and it is widely used in protein analysis, gene sequencing, biomarker detection, and other fields. The confined space of the nanopore provides a place for dynamic interactions and chemical reactions between substances. The use of nanopore sensing technology to track these processes in real time is helpful to understand the interaction/reaction mechanism at the single-molecule level. According to nanopore materials, we summarize the development of biological nanopores and solid-state nanopores/nanochannels in the stochastic sensing of dynamic interactions and chemical reactions. The goal of this paper is to stimulate the interest of researchers and promote the development of this field.
纳米孔传感技术是一种新兴的分析方法，具有操作简单、灵敏度高、输出快速、无需标记等优点，广泛应用于蛋白质分析、基因测序、生物标志物检测等领域。纳米孔的限制空间为物质之间的动态相互作用和化学反应提供了场所。利用纳米孔传感技术实时跟踪这些过程有助于在单分子水平上理解相互作用/反应机制。根据纳米孔材料，我们总结了生物纳米孔和固态纳米孔/纳米通道在动态相互作用和化学反应的随机传感方面的发展。本文的目的是激发研究人员的兴趣，促进该领域的发展。
