Dorow P, Schenk H, Dougherty C
Arzneimittelforschung. 1986 Jun;36(6):974-6.
The goal of the current study was to determine whether administration of a methylxanthine preparation in the form of a retention enema (theophylline-diprophylline-proxyphylline combination, Neobiphyllin-Clys) has an effect similar to that of intravenous theophylline in the treatment of acute bronchospasm. In a randomized cross-over study 16 patients with a history of asthma were given 0.48 g of theophylline-ethylenediamine (TE) in the form of rapid intravenous infusion or a retention enema containing 400 mg theophylline, 600 mg diprophylline and 600 mg proxyphylline (TDP). Forced expiratory volume in the first second (FEV1) airways resistance (Rt) and serum theophylline levels were determined before administration of the drug and at 15 min, 30 min and hourly for a period of 6 h after administration of the medication. The results were significant at the 5% level. There were significant increases in serum theophylline levels with both TE and TDP. After administration of TE there were significant changes in FEV1 at 15 min and Rt at 30 min which persisted for 5 h after administration of the drug. Statistically significant differences in FEV1 were observed 60 min and in Rt 30 min after administration of TDP. These effects persisted for 6 h. The data document that a retention enema offers the advantage of prolonged action in comparison to intravenous infusion of theophylline in the treatment of acute bronchospasm.
本研究的目的是确定以保留灌肠剂形式给予甲基黄嘌呤制剂（茶碱 - 二羟丙茶碱 - 丙羟茶碱组合，新双羟丙茶碱灌肠剂）在治疗急性支气管痉挛方面是否具有与静脉注射茶碱相似的效果。在一项随机交叉研究中，16名有哮喘病史的患者接受了以快速静脉输注形式给予的0.48 g氨茶碱（TE）或含有400 mg茶碱、600 mg二羟丙茶碱和600 mg丙羟茶碱（TDP）的保留灌肠剂。在给药前以及给药后15分钟、30分钟和每小时一次，持续6小时测定第一秒用力呼气量（FEV1）、气道阻力（Rt）和血清茶碱水平。结果在5%水平上具有显著性。TE和TDP给药后血清茶碱水平均显著升高。给予TE后，15分钟时FEV1和30分钟时Rt有显著变化，且在给药后持续5小时。给予TDP后60分钟时FEV1和30分钟时Rt观察到统计学上的显著差异。这些作用持续6小时。数据表明，与静脉输注茶碱相比，保留灌肠剂在治疗急性支气管痉挛方面具有作用持续时间长的优势。
