Zou Jiyuan, Xia Han, Jiang Qianzhou, Su Zhikang, Wen Siyi, Liang Zitian, Ouyang Yuanting, Liu Jiaohong, Zhang Zhiyi, Chen Ding, Yang Li, Guo Lvhua
Guangzhou Medical University, Guangzhou, Guangdong, China.
Department of Prosthodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong, China.
Regen Ther. 2023 Jun 22;24:135-146. doi: 10.1016/j.reth.2023.05.008. eCollection 2023 Dec.
Odontogenic stem cells originate from cranial neural crest cells and offer unique advantages in the regeneration of dentin-pulp complex. There is increasing evidence that stem cells exert their biological functions mainly through exosome-based paracrine effects. Exosomes contain DNA, RNA, proteins, metabolites, etc., which can play a role in intercellular communication and have similar therapeutic potential to stem cells. In addition, compared with stem cells, exosomes also have the advantages of good biocompatibility, high drug carrying capacity, easy to obtain, and few side effects. Odontogenic stem cell-derived exosomes mainly affect the regeneration of the dentin-pulp complex by regulating processes such as dentintogenesis, angiogenesis, neuroprotection and immunomodulation. This review aimed to describe "cell-free therapies" based on odontogenic stem cell-derived exosomes, which aim to regenerate the dentin-pulp complex.
牙源性干细胞起源于颅神经嵴细胞，在牙本质-牙髓复合体再生方面具有独特优势。越来越多的证据表明，干细胞主要通过基于外泌体的旁分泌作用发挥其生物学功能。外泌体包含DNA、RNA、蛋白质、代谢产物等，可在细胞间通讯中发挥作用，并且具有与干细胞相似的治疗潜力。此外，与干细胞相比，外泌体还具有生物相容性好、药物携带能力高、易于获取和副作用少等优点。牙源性干细胞来源的外泌体主要通过调节牙本质形成、血管生成、神经保护和免疫调节等过程来影响牙本质-牙髓复合体的再生。本综述旨在描述基于牙源性干细胞来源外泌体的“无细胞疗法”，其目的是使牙本质-牙髓复合体再生。
