Hussain Abrar, Yasar Muhammad, Ahmad Gulzar, Ijaz Muhammad, Aziz Abdul, Nawaz Muhammad Gharib, Khan Faraz Ahmad, Iqbal Hamza, Shakeel Wajeeha, Momand Hashmat, Ali Rukhsar, Ahmad Sidra, Shah Hafsa, Nadeem Muhammad, Ahmad Dawood, Anjum Farida, Faisal Sulaiman
Department of Biotechnology, Institute of Integrative Biosciences, CECOS University Peshawar, Pakistan.
Department of Biotechnology and Genetic Engineering, Institute of Biotechnology and Genetic Engineering University of Agriculture, Pakistan.
Int J Health Sci (Qassim). 2023 Jul-Aug;17(4):3-10.
The green synthesis method for nanoparticles is getting more attention globally, due to its lesser cost, non-hazardous, and eco-friendly nature. The novelty of the present work is to investigate the anti-bacterial and degradation activity of the green synthesized Iron Oxide NPs.
In this study, the Iron Oxide NPs were synthesized through a green synthesis route from leaves of Ficus Palmata. UV-Vis confirmed Iron Oxide NP's peaks between (230-290 nm), while Fourier transforms infrared spectroscopy analysis showed that several groups were involved in reduction and stabilization.
Results indicated that the highest photo thermal activity was shown in light and it was almost 4 folds greater than the control. Similarly, Iron Oxide NPs showed excellent antimicrobial potential against bacterial species typhi" and at low concentrations (150 μg/mL). Hemolytic assay results showed that the toxicity was lesser than 5% at both dark and light conditions. Moreover, we also evaluated the photo-catalytic potential of Iron Oxide NPs against methylene orange. Results indicated that almost complete degradation was noted after 90 min in the presence of continuous light. All tests were performed in triplicates. All the data was subjected to -test ( < 0.5) using Excel and graph pad (V.5.0).
Iron Oxide NPs holds a promising future and could be used in treating diseases, and microbial pathogenesis and also could be used as a vector in drug delivery. Moreover, they can also eradicate persistent dyes and could be used as an alternative to remediate pollutants from the environment.
由于其成本较低、无危害且环保的特性，纳米颗粒的绿色合成方法在全球范围内受到越来越多的关注。本研究的新颖之处在于研究绿色合成的氧化铁纳米颗粒的抗菌和降解活性。
在本研究中，通过绿色合成路线从无花果叶中合成了氧化铁纳米颗粒。紫外可见光谱证实了氧化铁纳米颗粒在（230 - 290纳米）之间的峰，而傅里叶变换红外光谱分析表明有几个基团参与了还原和稳定过程。
结果表明，在光照下表现出最高的光热活性，几乎是对照组的4倍。同样，氧化铁纳米颗粒在低浓度（150微克/毫升）时对伤寒杆菌等细菌物种显示出优异的抗菌潜力。溶血试验结果表明，在黑暗和光照条件下毒性均小于5%。此外，我们还评估了氧化铁纳米颗粒对亚甲基橙的光催化潜力。结果表明，在持续光照下90分钟后几乎观察到完全降解。所有测试均重复进行三次。所有数据使用Excel和GraphPad（V.5.0）进行t检验（P < 0.05）。
氧化铁纳米颗粒具有广阔的前景，可用于治疗疾病、微生物致病机制，也可用作药物递送的载体。此外，它们还可以消除持久性染料，并可作为从环境中修复污染物的替代品。
