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哥伦比亚与严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)相关的呼吸道症状患者的病原菌描述。

Description of pathogenic bacteria in patients with respiratory symptoms associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Colombia.

机构信息

Centro de Investigaciones en Microbiología and Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.

Centro de Tecnología en Salud (CETESA), Innovaseq SAS, Bogotá, Colombia.

出版信息

Ann Clin Microbiol Antimicrob. 2023 Jul 7;22(1):56. doi: 10.1186/s12941-023-00595-x.

Abstract

Viral respiratory infections may predispose to co-infections with other pathogenic microorganisms. In this study, pathogenic respiratory bacteria were detected using commercial kit Allplex Respiratory Panel 4 from nasopharyngeal samples from individuals suffering respiratory symptoms with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients without respiratory symptoms were included as controls. Haemophilus influenzae and Streptococcus pneumoniae were detected from 12 patients (6%) in both, patients with respiratory symptoms (including hospitalized) (n = 6) and individual without symptoms (n = 6). Pathogenic bacteria possibly proliferate due to the limited immune response of patients with SARS-CoV-2, perhaps due to dysbiosis generated by the viral infection.

摘要

病毒呼吸道感染可能使患者易合并其他致病微生物感染。在这项研究中,使用商业试剂盒 Allplex Respiratory Panel 4 从有和无严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)症状的个体的鼻咽样本中检测到致病性呼吸道细菌。无呼吸道症状的患者被纳入对照组。在有呼吸道症状(包括住院)的患者(n=6)和无症状的个体(n=6)中,均从 12 名患者(6%)中检测到流感嗜血杆菌和肺炎链球菌。SARS-CoV-2 患者的免疫反应受限,可能是由于病毒感染引起的微生态失调,导致这些致病性细菌可能大量繁殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d0/10326947/a5347860c710/12941_2023_595_Fig1_HTML.jpg

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