Department of Molecular Diagnostics, HealthTrackRX, Denton, TX 76207, USA.
Department of Molecular Diagnostics, HealthTrackRX, Denton, TX 76207, USA.
Int J Infect Dis. 2021 Apr;105:617-620. doi: 10.1016/j.ijid.2021.02.087. Epub 2021 Feb 25.
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented challenge to our healthcare system. Secondary and concurrent bacterial and viral co-infections are well documented for other viral respiratory pathogens; however knowledge regarding co-infections in COVID-19 remains limited. In the present study, concurrent testing of 50 419 individual samples for the presence of SARS-CoV-2 and other bacterial and viral respiratory pathogens was performed between March and August 2020. Overall, a lower rate of viral co-infection was observed in the SARS-CoV-2-positive population when compared to the population testing negative for the virus. Significant levels of Staphylococcus aureus and Epstein-Barr virus co-infections were detected in the SARS-CoV-2-positive population. This is one of the largest surveys looking into the co-infection patterns of SARS-CoV-2 infection in the United States. Data from this study will enhance our understanding of the current pandemic and will assist clinicians in making better patient care decisions, especially with respect to antimicrobial therapy.
全球 2019 年冠状病毒病（COVID-19）大流行是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的，这对我们的医疗保健系统造成了前所未有的挑战。其他病毒性呼吸道病原体的继发性和并发细菌和病毒合并感染已有充分记录；然而，关于 COVID-19 合并感染的知识仍然有限。在本研究中，于 2020 年 3 月至 8 月间对 50419 份个体样本同时进行了 SARS-CoV-2 和其他细菌和病毒呼吸道病原体的检测。总体而言，与病毒检测阴性的人群相比，SARS-CoV-2 阳性人群中的病毒合并感染率较低。在 SARS-CoV-2 阳性人群中检测到了金黄色葡萄球菌和 Epstein-Barr 病毒的合并感染。这是在美国对 SARS-CoV-2 感染合并感染模式进行的最大规模调查之一。本研究的数据将增强我们对当前大流行的认识，并有助于临床医生做出更好的患者护理决策，特别是在抗菌治疗方面。
