Ceja-Galicia Zeltzin Alejandra, García-Arroyo Fernando Enrique, Aparicio-Trejo Omar Emiliano, El-Hafidi Mohammed, Gonzaga-Sánchez Guillermo, León-Contreras Juan Carlos, Hernández-Pando Rogelio, Guevara-Cruz Martha, Tovar Armando R, Rojas-Morales Pedro, Aranda-Rivera Ana Karina, Sánchez-Lozada Laura Gabriela, Tapia Edilia, Pedraza-Chaverri José
Department of Cardio-Renal Physiology, National Institute of Cardiology "Ignacio Chávez", Mexico City 14080, Mexico.
Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City 04510, Mexico.
Antioxidants (Basel). 2022 Nov 6;11(11):2195. doi: 10.3390/antiox11112195.
Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However, the mechanisms of CKD dyslipidemia are not fully understood. The use of curcumin (CUR) in CKD models such as 5/6 nephrectomy (5/6Nx) has shown multiple beneficial effects, so it has been proposed to correct dyslipidemia without side effects. This work aimed to characterize CUR's potential therapeutic effect on dyslipidemia and alterations in lipid metabolism and mitochondrial ß-oxidation in the liver and kidney in 5/6Nx. Male Wistar rats were subjected to 5/6Nx and progressed by 4 weeks; meanwhile, CUR (120 mg/kg) was administered for weeks 5 to 8. Our results showed that CUR reversed the increase in liver and kidney damage and hypertriglyceridemia induced by 5/6Nx. CUR also reversed mitochondrial membrane depolarization and β-oxidation disorders in the kidney and the increased lipid uptake and the high levels of proteins involved in fatty acid synthesis in the liver and kidney. CUR also decreased lipogenesis and increased mitochondrial biogenesis markers in the liver. Therefore, we concluded that the therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia is associated with the restoration of renal mitochondrial ß-oxidation and the reduction in lipid synthesis and uptake in the kidneys and liver.
慢性肾脏病（CKD）的患病率持续上升，该疾病中的血脂异常具有特征性，易引发心血管事件。然而，CKD血脂异常的机制尚未完全明确。在诸如5/6肾切除（5/6Nx）的CKD模型中使用姜黄素（CUR）已显示出多种有益作用，因此有人提出它可纠正血脂异常且无副作用。这项工作旨在表征CUR对5/6Nx大鼠血脂异常以及肝脏和肾脏脂质代谢及线粒体β氧化改变的潜在治疗作用。雄性Wistar大鼠接受5/6Nx手术并持续4周；同时，在第5至8周给予CUR（120毫克/千克）。我们的结果表明，CUR可逆转5/6Nx诱导的肝脏和肾脏损伤增加以及高甘油三酯血症。CUR还可逆转肾脏中的线粒体膜去极化和β氧化紊乱，以及肝脏和肾脏中脂质摄取增加和参与脂肪酸合成的蛋白质水平升高。CUR还可减少肝脏中的脂肪生成并增加线粒体生物发生标志物。因此，我们得出结论，姜黄素对5/6Nx高甘油三酯血症的治疗作用与恢复肾脏线粒体β氧化以及减少肾脏和肝脏中的脂质合成与摄取有关。
