Khutami Chindiana, Sumiwi Sri Adi, Khairul Ikram Nur Kusaira, Muchtaridi Muchtaridi
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Sumedang 45363, Indonesia.
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Int J Mol Sci. 2022 Feb 12;23(4):2056. doi: 10.3390/ijms23042056.
Obesity is a risk factor that leads to the development of other diseases such as dyslipidemia and diabetes. These three metabolic disorders can occur simultaneously, hence, the treatment requires many drugs. Antioxidant compounds have been reported to have activities against obesity, dyslipidemia and diabetes via several mechanisms. This review aims to discuss the antioxidant compounds that have activity against obesity, dyslipidemia and diabetes together with their molecular signaling mechanism. The literature discussed in this review was obtained from the PUBMED database. Based on the collection of literature obtained, antioxidant compounds having activity against the three disorders (obesity, dyslipidemia and diabetes) were identified. The activity is supported by various molecular signaling pathways that are influenced by these antioxidant compounds, further study of which would be useful in predicting drug targets for a more optimal effect. This review provides insights on utilizing one of these antioxidant compounds as opposed to several drugs. It is hoped that in the future, the number of drugs in treating obesity, dyslipidemia and diabetes altogether can be minimized consequently reducing the risk of side effects.
肥胖是导致其他疾病如血脂异常和糖尿病发生的一个风险因素。这三种代谢紊乱可能同时出现，因此，治疗需要多种药物。据报道，抗氧化化合物可通过多种机制对抗肥胖、血脂异常和糖尿病。本综述旨在讨论具有抗肥胖、血脂异常和糖尿病活性的抗氧化化合物及其分子信号传导机制。本综述中讨论的文献来自PUBMED数据库。基于所获得的文献收集，确定了具有抗这三种疾病（肥胖、血脂异常和糖尿病）活性的抗氧化化合物。这些抗氧化化合物所影响的各种分子信号通路支持了这种活性，对其进一步研究将有助于预测药物靶点以获得更优效果。本综述提供了关于使用这些抗氧化化合物之一而非多种药物的见解。希望未来在治疗肥胖、血脂异常和糖尿病时能减少药物数量，从而降低副作用风险。
