脂联素水平与青少年代谢综合征的相关性研究
Lipid accumulation product is a better predictor of metabolic syndrome in Chinese adolescents: a cross-sectional study.
机构信息
Institute of Health Sciences, China Medical University, Shenyang, Liaoning, China.
School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China.
出版信息
Front Endocrinol (Lausanne). 2023 Jun 23;14:1179990. doi: 10.3389/fendo.2023.1179990. eCollection 2023.
AIM
Confirm and compare the degree of associations of non-traditional lipid profiles and metabolic syndrome (MetS) in Chinese adolescents, determine the lipid parameter with better predictive potential, and investigate their discriminatory power on MetS.
METHODS
Medical measurements, including anthropometric measurements and biochemical blood tests, were undergone among a total sample of 1112 adolescents (564 boys and 548 girls) aged from 13 to 18 years. Univariate and multivariate logistic regression analyses were applied for assessing the relationships between the levels of traditional/non-traditional lipid profiles and MetS. We performed Receiver Operating Characteristic (ROC) analyses to mensurate the effectiveness of lipid accumulation product (LAP) on the diagnosis of MetS. Meanwhile, areas under the ROC curve and the cut-off values were calculated for MetS and its components.
RESULTS
Univariate analysis showed that all our lipid profiles were closely associated with MetS (P< 0.05). LAP index showed the closest association with MetS than the other lipid profiles. Additionally, ROC analyses indicated that the LAP index showed sufficient capabilities to identify adolescents with MetS and its components.
CONCLUSION
The LAP index is a simple and efficient tool to identify individuals with MetS in Chinese adolescents.
目的
确认并比较非传统血脂谱与代谢综合征（MetS）在青少年中的关联程度，确定预测能力更好的血脂参数，并探讨其对 MetS 的判别能力。
方法
对 1112 名年龄在 13 至 18 岁的青少年（男 564 名，女 548 名）进行了医学测量，包括人体测量和生化血液检测。采用单因素和多因素逻辑回归分析评估传统/非传统血脂谱与 MetS 之间的关系。我们进行了接收者操作特征（ROC）分析，以衡量脂积聚产物（LAP）对 MetS 诊断的有效性。同时，计算了 MetS 及其各组分的 ROC 曲线下面积和截断值。
结果
单因素分析表明，我们所有的血脂谱均与 MetS 密切相关（P<0.05）。LAP 指数与 MetS 的相关性最密切。此外，ROC 分析表明，LAP 指数具有足够的能力来识别患有 MetS 及其各组分的青少年。
结论
LAP 指数是一种简单有效的工具，可用于识别中国青少年中的 MetS 患者。
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