McGuinness E E, Morgan R G, Wormsley K G
Environ Health Perspect. 1984 Jun;56:205-12. doi: 10.1289/ehp.8456205.
We have reviewed the growth-promoting and carcinogenic effects of feeding raw soya flour to rats. If the raw soya flour-containing diets are fed for more than a year, about 10% of the animals develop pancreatic cancer. In addition, feeding raw soya flour markedly potentiates the action of even subthreshold amounts of pancreatic carcinogens. The raw soya flour therefore acts as a potent promoter, as well as a weak carcinogen. In view of this promotion, the rat fed raw soya flour is a sensitive model for screening pancreatic carcinogens. It is not known whether the human pancreas responds to dietary trypsin inhibitors in a manner similar to the rat. However, in view of the use of soya-based products in human nutrition--especially in infant foods--we urge that the effect of all soya-based products intended for human use be tested on the rat pancreas in long-term feeding studies, combined with subthreshold doses of azaserine to highlight any promoting activity of the product. It seems probable that if a product exerts no effect on the rat pancreas, the human pancreas will also be spared from noxious effects.
我们已经回顾了给大鼠喂食生大豆粉的促生长和致癌作用。如果喂食含生大豆粉的日粮超过一年，约10%的动物会患上胰腺癌。此外，喂食生大豆粉能显著增强即使是亚阈值剂量的胰腺致癌物的作用。因此，生大豆粉既是一种强效的促癌剂，也是一种弱致癌物。鉴于这种促进作用，喂食生大豆粉的大鼠是筛选胰腺致癌物的敏感模型。尚不清楚人类胰腺对膳食胰蛋白酶抑制剂的反应是否与大鼠相似。然而，鉴于大豆基产品在人类营养中的应用——尤其是在婴儿食品中——我们敦促，所有供人类使用的大豆基产品的效果应在长期喂养研究中对大鼠胰腺进行测试，并结合亚阈值剂量的偶氮丝氨酸，以突出该产品的任何促癌活性。如果一种产品对大鼠胰腺没有影响，那么人类胰腺似乎也可能不会受到有害影响。
