Morgan R G, Levinson D A, Hopwood D, Saunders J H, Wormsley K G
Cancer Lett. 1977 Jul;3(1-2):87-90. doi: 10.1016/s0304-3835(77)94455-x.
Rats were treated with raw soya flour to produce pancreatic hypertrophy and also received azaserine, a pancreatic carcinogen. The combined treatment resulted in the development of large numbers of hyperplastic nodules in the acinar tissue of the rat pancreas. We conclude that the pancreas of the rat stimulated to proliferate by raw soya flour provides a sensitive model for detecting and studying pancreatic carcinogens.
用生大豆粉处理大鼠以诱发胰腺肥大，同时给予胰腺致癌物偶氮丝氨酸。联合处理导致大鼠胰腺腺泡组织中出现大量增生性结节。我们得出结论，受生大豆粉刺激而增殖的大鼠胰腺为检测和研究胰腺致癌物提供了一个敏感模型。
