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二(2-羟丙基)亚硝胺(DHPN)对雄性Wistar大鼠的致癌作用:生大豆粉饮食对胰腺癌的促进作用。

Carcinogenic effects of Di(2-hydroxypropyl)nitrosamine (DHPN) in male Wistar rats: promotion of pancreatic cancer by a raw soya flour diet.

作者信息

Levison D A, Morgan R G, Brimacombe J S, Hopwood D, Coghill G, Wormsley K G

出版信息

Scand J Gastroenterol. 1979;14(2):217-24. doi: 10.3109/00365527909179873.

DOI:10.3109/00365527909179873
PMID:571138
Abstract

Di(2-hydroxypropyl)nitrosamine was administered to rats fed raw or heated (control) soya flour diets. The group fed raw soya flour developed hyperplastic and adenomatous pancreatic nodules and pancreatic adenocarcinomata. We conclude that a diet of raw soya flour augments the carcinogenicity of pancreatic carcinogens in the rat.

摘要

将二(2-羟丙基)亚硝胺给予喂食生大豆粉或加热(对照)大豆粉饮食的大鼠。喂食生大豆粉的组出现了增生性和腺瘤性胰腺结节以及胰腺腺癌。我们得出结论,生大豆粉饮食会增强大鼠胰腺致癌物的致癌性。

相似文献

1
Carcinogenic effects of Di(2-hydroxypropyl)nitrosamine (DHPN) in male Wistar rats: promotion of pancreatic cancer by a raw soya flour diet.二(2-羟丙基)亚硝胺(DHPN)对雄性Wistar大鼠的致癌作用:生大豆粉饮食对胰腺癌的促进作用。
Scand J Gastroenterol. 1979;14(2):217-24. doi: 10.3109/00365527909179873.
2
The effects of long-term feeding of soya flour on the rat pancreas.长期喂食大豆粉对大鼠胰腺的影响。
Scand J Gastroenterol. 1980;15(4):497-502. doi: 10.3109/00365528009181507.
3
Potentiation of the action of azaserine on the rat pancreas by raw soya bean flour.生大豆粉增强重氮丝氨酸对大鼠胰腺的作用。
Cancer Lett. 1977 Jul;3(1-2):87-90. doi: 10.1016/s0304-3835(77)94455-x.
4
Interaction of azaserine and raw soya flour on the rat pancreas.重氮丝氨酸与生大豆粉对大鼠胰腺的相互作用。
Scand J Gastroenterol. 1981;16(1):49-56.
5
Further studies of the effects of raw soya flour on the rat pancreas.生大豆粉对大鼠胰腺影响的进一步研究。
Scand J Gastroenterol. 1982 Mar;17(2):273-7. doi: 10.3109/00365528209182052.
6
Effects of feeding partial and intermittent raw soya flour diets on the rat pancreas.喂食部分和间歇性生大豆粉日粮对大鼠胰腺的影响。
Cancer Lett. 1986 Jul;32(1):73-81. doi: 10.1016/0304-3835(86)90041-8.
7
Effects of soybean flour on the pancreas of rats.大豆粉对大鼠胰腺的影响。
Environ Health Perspect. 1984 Jun;56:205-12. doi: 10.1289/ehp.8456205.
8
Histochemical elucidation of hamster pancreatic carcinogenesis induced by N-nitroso-bis (2-hydroxypropyl) amine.N-亚硝基双(2-羟丙基)胺诱导仓鼠胰腺癌发生的组织化学阐明
Nihon Geka Hokan. 1982 Jan 1;51(1):3-13.
9
The effect of long-term feeding of soya-bean flour diets on pancreatic growth in the rat.长期喂食大豆粉日粮对大鼠胰腺生长的影响。
Br J Nutr. 1982 Jan;47(1):119-29. doi: 10.1079/bjn19820017.
10
The effects of soy flour and N-nitrosobis (2-oxopropyl) amine on the pancreas of the hamster.大豆粉和N-亚硝基双(2-氧代丙基)胺对仓鼠胰腺的影响。
Drug Nutr Interact. 1985;3(3):173-9.

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Protective effect of Emilia sonchifolia (L.) against high protein diet induced oxidative stress in pancreas of Wistar rats.一点红对高蛋白饮食诱导的Wistar大鼠胰腺氧化应激的保护作用。
J Pharm Bioallied Sci. 2012 Jan;4(1):60-5. doi: 10.4103/0975-7406.92735.
2
Experimental pancreatic hyperplasia and neoplasia: effects of dietary and surgical manipulation.实验性胰腺增生和肿瘤形成:饮食及手术操作的影响
Br J Cancer. 1993 May;67(5):877-84. doi: 10.1038/bjc.1993.165.
3
Modification of pancreatic carcinogenesis in the hamster model. 2. The effect of partial pancreatectomy.
仓鼠模型中胰腺癌发生的改变。2. 胰腺部分切除术的影响。
Am J Pathol. 1983 Jan;110(1):75-82.
4
Effects of soybean flour on the pancreas of rats.大豆粉对大鼠胰腺的影响。
Environ Health Perspect. 1984 Jun;56:205-12. doi: 10.1289/ehp.8456205.
5
Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil.
Virchows Arch A Pathol Anat Histopathol. 1985;405(3):285-97. doi: 10.1007/BF00710065.
6
Longterm pancreaticobiliary diversion stimulates hyperplastic and adenomatous nodules in the rat pancreas: a new model for spontaneous tumour formation.长期胰胆转流刺激大鼠胰腺中的增生性和腺瘤性结节:一种自发性肿瘤形成的新模型。
Gut. 1987;28 Suppl(Suppl):265-8. doi: 10.1136/gut.28.suppl.265.
7
Induction of pancreatic tumours by longterm duodenogastric reflux.
Gut. 1989 Nov;30(11):1596-600. doi: 10.1136/gut.30.11.1596.
8
Induction of a mixed ductal-squamous-islet cell carcinoma in a rat treated with a tobacco-specific carcinogen.在用一种烟草特异性致癌物处理的大鼠中诱导出混合性导管-鳞状-胰岛细胞癌。
Am J Pathol. 1989 Mar;134(3):627-31.
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Structural changes of the exocrine pancreas in a patient with cholecystolithiasis.一名胆囊结石患者外分泌胰腺的结构变化。
Int J Pancreatol. 1992 Aug;12(1):53-9. doi: 10.1007/BF02927070.