McGuinness E E, Morgan R G, Levison D A, Hopwood D, Wormsley K G
Scand J Gastroenterol. 1981;16(1):49-56.
Rats have been fed for up to 2 years with either raw soya flour or control diets of heated soya flour or rat chow not containing soya flour. In addition, the rats received weekly injections of either a weak pancreatic carcinogen (azaserine) or control injection of saline. We found that rats fed a diet of raw soya flour and given weekly injections of azaserine developed benign and malignant neoplasms of the pancreas earlier in life and much more frequently than rats given raw soya flour alone, whereas azaserine alone in the dose used in this study did not produce pancreatic cancer. We conclude that raw soya flour sensitizes the pancreas to the action of azaserine.
用生大豆粉或加热大豆粉的对照饮食或不含大豆粉的大鼠饲料喂养大鼠长达2年。此外，给大鼠每周注射一次弱胰腺致癌物（偶氮丝氨酸）或注射生理盐水作为对照。我们发现，食用生大豆粉饮食并每周注射偶氮丝氨酸的大鼠，比仅食用生大豆粉的大鼠更早且更频繁地发生胰腺良性和恶性肿瘤，而在本研究中使用的剂量下，单独使用偶氮丝氨酸不会诱发胰腺癌。我们得出结论，生大豆粉使胰腺对偶氮丝氨酸的作用敏感。
