Janoff A S, Rauch J
Chem Phys Lipids. 1986 Jun-Jul;40(2-4):315-32. doi: 10.1016/0009-3084(86)90076-9.
Antibodies to phospholipids represent a unique set of incompletely characterized antibodies prevalent in patients with systemic lupus erythematosus and related autoimmune disorders. Little is known concerning their induction and pathogenesis. Here we provide an overview of what is currently known about these antibodies and explore the possibility that they interact with and are perhaps specific for unusual lipid structures. Particular attention is given to the physical chemical nature and phase behaviour of associated putative lipid antigens. This analysis suggests that alterations in the phospholipid architecture of cell membranes may play an important role in the immunoregulation of autoimmunity.
抗磷脂抗体是一组独特的、特征尚未完全明确的抗体，在系统性红斑狼疮及相关自身免疫性疾病患者中普遍存在。关于它们的诱导机制和发病机制知之甚少。在此，我们概述了目前对这些抗体的了解，并探讨它们与异常脂质结构相互作用且可能对其具有特异性的可能性。我们特别关注相关假定脂质抗原的物理化学性质和相行为。该分析表明，细胞膜磷脂结构的改变可能在自身免疫的免疫调节中起重要作用。
