六方II相磷脂具有免疫原性：体内非双层脂质相免疫识别的证据。
Phospholipid in the hexagonal II phase is immunogenic: evidence for immunorecognition of nonbilayer lipid phases in vivo.
作者信息
Rauch J, Janoff A S
机构信息
Division of Rheumatology, Montreal General Hospital Research Institute, McGill University, PQ, Canada.
出版信息
Proc Natl Acad Sci U S A. 1990 Jun;87(11):4112-4. doi: 10.1073/pnas.87.11.4112.
Abstract
Immunization of mice with phosphatidylethanolamine in the hexagonal II phase but not the bilayer phase resulted in the induction of anti-phospholipid antibodies. These antibodies, which were strongly reactive with phosphatidylethanolamine and crossreactive with cardiolipin, had functional lupus anticoagulant activity and were characteristic of autoantibodies common in patients with autoimmune disease. Recognition of the hexagonal II phase by the afferent limb of the immune system suggests that nonbilayer phospholipids can arise in the course of membrane remodeling and induce the autoantibodies of disease.
摘要
用处于六方II相而非双分子层相的磷脂酰乙醇胺免疫小鼠，会诱导抗磷脂抗体的产生。这些抗体与磷脂酰乙醇胺强烈反应且与心磷脂交叉反应，具有功能性狼疮抗凝活性，是自身免疫病患者中常见的自身抗体特征。免疫系统的传入支对六方II相的识别表明，非双分子层磷脂可能在膜重塑过程中出现并诱导疾病的自身抗体产生。
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