Eid Mahfoud, Ghanem Abd, Saloum Elias
Department of Pediatrics.
Faculty of Human Medicine, Tishreen University, Latakia, Syria.
Ann Med Surg (Lond). 2023 Jun 8;85(7):3666-3669. doi: 10.1097/MS9.0000000000000877. eCollection 2023 Jul.
Cytomegalovirus (CMV) is a widespread virus, and it affects people of all ages. Infection with this virus causes severe life-threatening disease in immunocompromised patients and newborns. While CMV infection is asymptomatic or present as a mild illness in most cases of immunocompetent patient, it may cause severe diseases in 10% of cases.
Here, the authors describe the case of an 11-year-old male presented with an ischemic stroke due to sickle cell disease; who, during hospitalization, developed a prolonged fever. After excluding bacterial infections, infiltrating diseases, rheumatologic diseases, malignancies, and other possible causes, he was diagnosed with CMV infection, which not checked initially, because most cases are asymptomatic.
This case highlights the need to consider CMV infection in the differential diagnosis of every case of fever of unknown origin, regardless of the patient's immune status.
巨细胞病毒(CMV)是一种广泛传播的病毒,可感染各年龄段人群。该病毒感染会在免疫功能低下的患者和新生儿中引发严重的危及生命的疾病。虽然在大多数免疫功能正常的患者中,CMV感染无症状或表现为轻症,但在10%的病例中可能导致严重疾病。
在此,作者描述了一名11岁男性因镰状细胞病出现缺血性中风的病例;该患者在住院期间出现持续发热。在排除细菌感染、浸润性疾病、风湿性疾病、恶性肿瘤及其他可能病因后,他被诊断为CMV感染,最初未进行检查是因为大多数病例无症状。
该病例强调,无论患者免疫状态如何,在不明原因发热的每例鉴别诊断中都需要考虑CMV感染。