近亲婚姻对生殖损耗的影响。

The effect of consanguineous marriages on reproductive wastage.

作者信息

Al-Awadi S A, Naguib K K, Moussa M A, Farag T I, Teebi A S, el-Khalifa M Y

出版信息

Clin Genet. 1986 May;29(5):384-8. doi: 10.1111/j.1399-0004.1986.tb00509.x.

DOI:10.1111/j.1399-0004.1986.tb00509.x

Abstract

A stratified representative sample size of 5,007 Kuwaiti females aged 15 years and above was drawn during 1983 and structurally interviewed to study the influence of consanguineous marriages (up to the second cousin) on reproductive wastage. Losses comprised prenatal deaths (abortions and stillbirths) and neonatal deaths (up to the first month of life). The rate of consanguineous mating in the sample was 54.3% with 95% confidence limits estimated rate 52.9% to 55.7% when projected over the whole Kuwaiti population. First cousin marriages accounted for 30.2% of the sample followed by 22.1% less than first cousin (first cousin once removed and second cousins) and 2% only double first cousin. The study showed higher prenatal and neonatal losses among consanguineous (14.2%, 2.97%) than nonconsanguineous (13.97%, 2.54%) although not statistically significant. No consistent increase in reproductive wastage was evident as the inbreeding coefficient, F, advances mainly because of decline in the wastage rate among the double first cousin marriages which represents only 2% of our sample.

摘要

1983年抽取了一个分层代表性样本，样本包括5007名15岁及以上的科威特女性，并对她们进行了结构化访谈，以研究近亲结婚（二级表亲及以内）对生殖损耗的影响。损耗包括产前死亡（流产和死产）和新生儿死亡（出生后第一个月内）。样本中的近亲交配率为54.3%，若将其推算至整个科威特人口，95%置信区间估计的近亲交配率为52.9%至55.7%。一级表亲结婚占样本的30.2%，其次是远亲（隔代一级表亲及二级表亲）占22.1%，仅双重一级表亲占2%。研究表明，近亲结婚者（14.2%，2.97%）的产前和新生儿损耗率高于非近亲结婚者（13.97%，2.54%），不过差异无统计学意义。随着近亲系数F增大，生殖损耗并无持续增加，这主要是因为双重一级表亲结婚者的损耗率下降，而双重一级表亲结婚者仅占我们样本的2%。