Univ. Lille, INSERM, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000 Lille, France.
CHU Lille, Clinical Neurophysiology Department, F-59000 Lille, France.
Neurobiol Aging. 2023 Oct;130:30-39. doi: 10.1016/j.neurobiolaging.2023.06.008. Epub 2023 Jun 16.
Electroencephalography's (EEG) sensitivity in discriminating dementia syndromes remains unclear. This study aimed to investigate EEG markers in patients with major cognitive disorders. The studied population included 4 groups of patients: Alzheimer's disease with associated vascular lesions, Alzheimer's disease without vascular lesions (AD-V), Lewy body disease and vascular dementia (VaD); and completed by a control group composed by cognitively unimpaired patients. EEGs were analysed quantitatively using spectral analysis, functional connectivity and micro-states. By comparison to the controls, expected slowing and alterations of functional connectivity were detected in patients with dementia. Among these patients, an overall increase in power in the alpha band was observed in the VaD group, mainly when compared to the 2 AD groups, while the Alzheimer's disease without vascular lesions group exhibited increased power in the beta-2 band and higher functional connectivity in the same frequency band. Micro-state analyses revealed differences in temporal dynamics for the VaD group. A number of EEG modifications reported as markers of some syndromes were found, but others were not reproduced.
脑电图（EEG）在鉴别痴呆综合征方面的敏感性尚不清楚。本研究旨在探讨主要认知障碍患者的脑电图标志物。研究人群包括 4 组患者：伴有血管病变的阿尔茨海默病、无血管病变的阿尔茨海默病（AD-V）、路易体病和血管性痴呆（VaD）；并由认知正常的患者组成对照组。脑电图使用频谱分析、功能连接和微状态进行定量分析。与对照组相比，痴呆患者的脑电图表现出预期的减慢和功能连接的改变。在这些患者中，VaD 组的 alpha 波段的功率总体增加，主要与 2 个 AD 组相比，而 AD-V 组的 beta-2 波段的功率增加，相同频段的功能连接增加。微状态分析显示 VaD 组在时间动态方面存在差异。报道了一些作为某些综合征标志物的脑电图改变，但其他改变没有重现。
