Social Determinants in Health Promotion Research Center, Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
J Health Popul Nutr. 2023 Jul 11;42(1):67. doi: 10.1186/s41043-023-00410-5.
The triglyceride glucose (TyG) and triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-c) are the indices that can predict the progression of pre-diabetes to type 2 diabetes mellitus (T2DM). This study aimed to examine the relationship between TyG and TG/HDL-c indices with the incidence of T2DM in pre-diabetes patients.
A total of 758 pre-diabetic patients aged 35-70 years who were enrolled in a prospective Fasa Persian Adult Cohort were followed up for 60 months. TyG and TG/HDL-C indices were obtained at baseline data and divided into quartiles. The 5-year cumulative incidence of T2DM was analyzed by Cox proportional hazards regression analysis while controlling for baseline covariates.
During 5 years of follow-up, there were 95 incident cases of T2DM, with an overall incidence rate of 12.53%. After adjusting for age, sex, smoking, marital status, socioeconomic status, body mass index, waist circumference, hip circumference, hypertension, total cholesterol, and dyslipidemia, the multivariate-adjusted hazard ratios (HRs) demonstrated that patients with the highest TyG and TG/HDL-C indices quartile were at higher risk of T2DM (HR = 4.42, 95%CI 1.75-11.21) and (HR = 2.15, 95%CI 1.04-4.47), respectively, compared to participants in the lowest quartile. As the quantiles of these indices increase, the HR value shows a significant increment (P < 0.05).
The results of our study showed that the TyG and TG/HDL-C indices can be important independent predictors for the progression of pre-diabetes to T2DM. Therefore, controlling the components of these indicators in pre-diabetes patients can prevent developing T2DM or delay its occurrence.
三酰甘油葡萄糖（TyG）和三酰甘油与高密度脂蛋白胆固醇比值（TG/HDL-c）是预测糖尿病前期进展为 2 型糖尿病（T2DM）的指标。本研究旨在探讨 TyG 和 TG/HDL-c 指数与糖尿病前期患者 T2DM 发病率的关系。
共纳入 758 名年龄在 35-70 岁的糖尿病前期患者，他们参加了前瞻性的 Fasa 波斯成人队列研究，并随访 60 个月。在基线数据中获得 TyG 和 TG/HDL-C 指数，并将其分为四分位数。通过 Cox 比例风险回归分析控制基线协变量后，分析 5 年 T2DM 的累积发生率。
在 5 年的随访期间，共有 95 例 T2DM 病例发生，总发病率为 12.53%。调整年龄、性别、吸烟、婚姻状况、社会经济地位、体重指数、腰围、臀围、高血压、总胆固醇和血脂异常后，多变量调整后的危险比（HR）表明，TyG 和 TG/HDL-C 指数最高四分位数的患者发生 T2DM 的风险更高（HR=4.42，95%CI 1.75-11.21）和（HR=2.15，95%CI 1.04-4.47），与最低四分位数的参与者相比。随着这些指数的分位数增加，HR 值呈显著增加（P<0.05）。
本研究结果表明，TyG 和 TG/HDL-C 指数是糖尿病前期进展为 T2DM 的重要独立预测指标。因此，在糖尿病前期患者中控制这些指标的成分可以预防 T2DM 的发生或延迟其发生。
