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近年来动脉血栓形成研究中微流控技术的进展。

Recent advances in microfluidic technology of arterial thrombosis investigations.

机构信息

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.

Department of Laboratory Medicine, Chengdu Shangjin Nanfu Hospital/Shangjin Branch of West China Hospital, Sichuan University, Chengdu, China.

出版信息

Platelets. 2024 Dec;35(1):2316743. doi: 10.1080/09537104.2024.2316743. Epub 2024 Feb 23.

DOI:10.1080/09537104.2024.2316743
PMID:38390892
Abstract

Microfluidic technology has emerged as a powerful tool in studying arterial thrombosis, allowing researchers to construct artificial blood vessels and replicate the hemodynamics of blood flow. This technology has led to significant advancements in understanding thrombosis and platelet adhesion and aggregation. Microfluidic models have various types and functions, and by studying the fabrication methods and working principles of microfluidic chips, applicable methods can be selected according to specific needs. The rapid development of microfluidic integrated system and modular microfluidic system makes arterial thrombosis research more diversified and automated, but its standardization still needs to be solved urgently. One key advantage of microfluidic technology is the ability to precisely control fluid flow in microchannels and to analyze platelet behavior under different shear forces and flow rates. This allows researchers to study the physiological and pathological processes of blood flow, shedding light on the underlying mechanisms of arterial thrombosis. In conclusion, microfluidic technology has revolutionized the study of arterial thrombosis by enabling the construction of artificial blood vessels and accurately reproducing hemodynamics. In the future, microfluidics will place greater emphasis on versatility and automation, holding great promise for advancing antithrombotic therapeutic and prophylactic measures.

摘要

微流控技术已成为研究动脉血栓形成的有力工具,使研究人员能够构建人工血管并复制血流的血液动力学。这项技术使我们对血栓形成和血小板黏附和聚集有了更深入的了解。微流控模型有多种类型和功能,通过研究微流控芯片的制造方法和工作原理,可以根据具体需求选择适用的方法。微流控集成系统和模块化微流控系统的快速发展使动脉血栓形成研究更加多样化和自动化,但它的标准化仍亟待解决。微流控技术的一个关键优势是能够精确控制微通道中的流体流动,并在不同剪切力和流速下分析血小板的行为。这使研究人员能够研究血流的生理和病理过程,揭示动脉血栓形成的潜在机制。总之,微流控技术通过构建人工血管和精确复制血液动力学,彻底改变了动脉血栓形成的研究。在未来,微流控将更加注重多功能性和自动化,为推进抗血栓治疗和预防措施提供了广阔的前景。

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