Que Mengxin, Li Yujuan, Wang Xuan, Zhan Gaofeng, Luo Xiaoxiao, Zhou Zhiqiang
Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Department of Anesthesiology, Tongji Medical College, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Department of Oncology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Front Cell Neurosci. 2023 Jun 26;17:1188306. doi: 10.3389/fncel.2023.1188306. eCollection 2023.
Sleep plays an essential role in all studied animals with a nervous system. However, sleep deprivation leads to various pathological changes and neurobehavioral problems. Astrocytes are the most abundant cells in the brain and are involved in various important functions, including neurotransmitter and ion homeostasis, synaptic and neuronal modulation, and blood-brain barrier maintenance; furthermore, they are associated with numerous neurodegenerative diseases, pain, and mood disorders. Moreover, astrocytes are increasingly being recognized as vital contributors to the regulation of sleep-wake cycles, both locally and in specific neural circuits. In this review, we begin by describing the role of astrocytes in regulating sleep and circadian rhythms, focusing on: (i) neuronal activity; (ii) metabolism; (iii) the glymphatic system; (iv) neuroinflammation; and (v) astrocyte-microglia cross-talk. Moreover, we review the role of astrocytes in sleep deprivation comorbidities and sleep deprivation-related brain disorders. Finally, we discuss potential interventions targeting astrocytes to prevent or treat sleep deprivation-related brain disorders. Pursuing these questions would pave the way for a deeper understanding of the cellular and neural mechanisms underlying sleep deprivation-comorbid brain disorders.
睡眠在所有已研究的具有神经系统的动物中都起着至关重要的作用。然而，睡眠剥夺会导致各种病理变化和神经行为问题。星形胶质细胞是大脑中数量最多的细胞，参与多种重要功能，包括神经递质和离子稳态、突触和神经元调节以及血脑屏障维持；此外，它们还与多种神经退行性疾病、疼痛和情绪障碍有关。此外，星形胶质细胞越来越被认为是局部和特定神经回路中睡眠-觉醒周期调节的重要贡献者。在这篇综述中，我们首先描述星形胶质细胞在调节睡眠和昼夜节律中的作用，重点关注：（i）神经元活动；（ii）代谢；（iii）类淋巴系统；（iv）神经炎症；以及（v）星形胶质细胞-小胶质细胞相互作用。此外，我们综述了星形胶质细胞在睡眠剥夺合并症和睡眠剥夺相关脑疾病中的作用。最后，我们讨论了针对星形胶质细胞的潜在干预措施，以预防或治疗睡眠剥夺相关脑疾病。探讨这些问题将为更深入理解睡眠剥夺合并脑疾病的细胞和神经机制铺平道路。
