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2
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Blurring the Anatomical Lines in Extrahepatic Cholangiocarcinoma: An Integrated Clinic-Oncological and Exploratory Proteomic Comparison of Perihilar and Distal Tumors.肝外胆管癌中解剖学界限的模糊：肝门部和远端肿瘤的临床肿瘤学综合及探索性蛋白质组学比较
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A PLCB1-PI3K-AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression.PLCB1-PI3K-AKT 信号轴激活 EMT 促进胆管癌进展。
Cancer Res. 2021 Dec 1;81(23):5889-5903. doi: 10.1158/0008-5472.CAN-21-1538. Epub 2021 Sep 27.
2
HMGA1-TRIP13 axis promotes stemness and epithelial mesenchymal transition of perihilar cholangiocarcinoma in a positive feedback loop dependent on c-Myc.HMGA1-TRIP13 轴通过 c-Myc 依赖性正反馈环促进肝门部胆管癌的干性和上皮间质转化。
J Exp Clin Cancer Res. 2021 Mar 1;40(1):86. doi: 10.1186/s13046-021-01890-1.
3
WDR5 facilitates EMT and metastasis of CCA by increasing HIF-1α accumulation in Myc-dependent and independent pathways.WDR5 通过增加 Myc 依赖性和非依赖性途径中的 HIF-1α 积累促进 CCA 的 EMT 和转移。
Mol Ther. 2021 Jun 2;29(6):2134-2150. doi: 10.1016/j.ymthe.2021.02.017. Epub 2021 Feb 15.
4
The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer.法尼醇 X 受体在代谢性疾病、胃肠道癌和肝癌中的作用。
Nat Rev Gastroenterol Hepatol. 2021 May;18(5):335-347. doi: 10.1038/s41575-020-00404-2. Epub 2021 Feb 10.
5
Serum KIAA1199 is an advanced-stage prognostic biomarker and metastatic oncogene in cholangiocarcinoma.血清 KIAA1199 是胆管癌晚期的预后生物标志物和转移癌基因。
Aging (Albany NY). 2020 Nov 10;12(23):23761-23777. doi: 10.18632/aging.103964.
6
GATA6 promotes epithelial-mesenchymal transition and metastasis through MUC1/β-catenin pathway in cholangiocarcinoma.GATA6 通过 MUC1/β-连环蛋白通路促进胆管癌的上皮-间充质转化和转移。
Cell Death Dis. 2020 Oct 15;11(10):860. doi: 10.1038/s41419-020-03070-z.
7
Ubiquitin-conjugating enzyme E2T regulates cell proliferation and migration in cholangiocarcinoma.泛素连接酶 E2T 调节胆管癌中的细胞增殖和迁移。
Anticancer Drugs. 2020 Sep;31(8):836-846. doi: 10.1097/CAD.0000000000000955.
8
Annexin10 promotes extrahepatic cholangiocarcinoma metastasis by facilitating EMT via PLA2G4A/PGE2/STAT3 pathway.膜联蛋白 10 通过 PLA2G4A/PGE2/STAT3 通路促进肝外胆管癌转移 EMT。
EBioMedicine. 2019 Sep;47:142-155. doi: 10.1016/j.ebiom.2019.08.062. Epub 2019 Sep 3.
9
Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma.胆管癌中的转化生长因子-β（TGFβ）信号通路。
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10
Role of AKT and mTOR signaling pathways in the induction of epithelial-mesenchymal transition (EMT) process.AKT 和 mTOR 信号通路在诱导上皮-间充质转化（EMT）过程中的作用。
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胆管癌中新型上皮-间质转化相关蛋白及其治疗靶点：一篇综述

The novel epithelial-mesenchymal transition-related proteins and their therapeutic targets in cholangiocarcinoma: a narrative review.

作者信息

Kimawaha Phongsaran, Techasen Anchalee

机构信息

Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.

Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.

出版信息

J Gastrointest Oncol. 2023 Jun 30;14(3):1593-1612. doi: 10.21037/jgo-22-1126. Epub 2023 May 26.

DOI:10.21037/jgo-22-1126
PMID:37435208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10331758/
Abstract

BACKGROUND AND OBJECTIVE

Cholangiocarcinoma (CCA), a liver cancer of bile duct epithelial cells, is a severe health issue in northeastern Thailand. The epithelial-mesenchymal transition (EMT) is a crucial process in the development of CCA. To comprehend oncogenic EMT in CCA, several newly found EMT factors are being explored in these underlying pathways. This narrative review explained the latest and findings on the molecular mechanisms of 21 new EMT-related proteins that affect CCA progression.

METHODS

We evaluated the PubMed database for relevant articles that fulfilled our criteria for investigating the molecular pathways of the novel EMT markers involved in oncogenic EMT and how they contribute to CCA development, including cell proliferation, apoptosis, invasion, migration, and chemoresistance.

KEY CONTENT AND FINDINGS

We discuss the potential of these new EMT markers as diagnostic, prognostic, and therapeutic indicators for CCA and describe their underlying mechanisms in the development of the disease. The discovery of several oncogenic EMT proteins and their key signaling pathways and downstream targets will also broaden novel paths of investigation into the diagnosis and targeted treatment of CCA.

CONCLUSIONS

The EMT-related proteins that were found are good sources of knowledge and interesting information for future research. The possible ways to treat CCA that could be tested in clinical trials were also discussed.

摘要

背景与目的

胆管癌（CCA）是一种胆管上皮细胞肝癌，在泰国东北部是一个严重的健康问题。上皮-间质转化（EMT）是CCA发生发展中的一个关键过程。为了理解CCA中的致癌性EMT，人们正在这些潜在途径中探索几种新发现的EMT因子。这篇叙述性综述解释了影响CCA进展的21种新的EMT相关蛋白的分子机制的最新研究结果。

方法

我们在PubMed数据库中评估了相关文章，这些文章符合我们对参与致癌性EMT的新型EMT标志物的分子途径进行研究的标准，以及它们如何促进CCA的发展，包括细胞增殖、凋亡、侵袭迁移和化疗耐药性。

关键内容与研究结果

我们讨论了这些新的EMT标志物作为CCA诊断、预后和治疗指标的潜力，并描述了它们在疾病发展中的潜在机制。几种致癌性EMT蛋白及其关键信号通路和下游靶点的发现也将拓宽CCA诊断和靶向治疗的新研究途径。

结论

所发现的与EMT相关的蛋白是未来研究的良好知识来源和有趣信息。还讨论了可在临床试验中测试的治疗CCA的可能方法。