Coordination for the Innovation and Application of Science and Technology (CIACYT), Universidad Autónoma de San Luis Potosí, 550-2a Sierra Leona Ave, San Luis Potosí 78210, Mexico.
ACS Appl Bio Mater. 2023 Aug 21;6(8):2982-2994. doi: 10.1021/acsabm.3c00284. Epub 2023 Jul 12.
Conditions, accidents, and aging processes have brought with them the need to develop implants with higher technology that allow not only the replacement of missing tissue but also the formation of tissue and the recovery of its function. The development of implants is due to advances in different areas such as molecular-biochemistry (which allows the understanding of the molecular/cellular processes during tissue repair), materials engineering, tissue regeneration (which has contributed advances in the knowledge of the properties of the materials used for their manufacture), and the so-called intelligent biomaterials (which promote tissue regeneration through inductive effects of cell signaling in response to stimuli from the microenvironment to generate adhesion, migration, and cell differentiation processes). The implants currently used are combinations of biopolymers with properties that allow the formation of scaffolds with the capacity to mimic the characteristics of the tissue to be repaired. This review describes the advances of intelligent biomaterials in implants applied in different dental and orthopedic problems; by means of these advances, it is expected to overcome limitations such as additional surgeries, rejections and infections in implants, implant duration, pain mitigation, and mainly, tissue regeneration.
条件、事故和衰老过程带来了需要开发具有更高技术的植入物的需求，这些植入物不仅可以替代缺失的组织，还可以形成组织并恢复其功能。植入物的发展得益于不同领域的进步，如分子-生物化学（它允许理解组织修复过程中的分子/细胞过程）、材料工程、组织再生（它促进了对用于制造它们的材料的特性的知识的进步）和所谓的智能生物材料（通过响应微环境刺激的细胞信号的诱导作用来促进组织再生，从而产生粘附、迁移和细胞分化过程）。目前使用的植入物是具有形成支架能力的生物聚合物的组合，这些支架具有模仿待修复组织特征的能力。这篇综述描述了智能生物材料在应用于不同牙科和骨科问题的植入物中的进展；通过这些进展，预计可以克服一些限制，如额外的手术、植入物的排斥和感染、植入物的持续时间、减轻疼痛，以及主要的组织再生。
