Dpto. de Óptica, Universidad Complutense de Madrid, Av. Arcos del Jalón 118, Madrid, E-28037, Spain.
Dpto.de Optometría y Visión, Universidad Complutense de Madrid, Av. Arcos del Jalón 118, Madrid, E-28037, Spain.
Graefes Arch Clin Exp Ophthalmol. 2024 Dec;262(12):3905-3913. doi: 10.1007/s00417-024-06590-y. Epub 2024 Jul 24.
The aim of this study is to compare optical quality results obtained in laboratory analysis (in vitro) versus clinical data (in vivo).
The optical quality of ISOPure intraocular lens was assessed both in vitro and in vivo using the modulation transfer function (MTF) for 3.0 and 4.5 mm pupil diameters. In vitro measurements were obtained using deflectometer NIMO TRF1504, while in vivo measurements were taken with OPD-Scan III in a set of patients implanted with this lens. Ray tracing techniques were used to determine the MTF and area under MTF curve (MTFa) from the measured wavefront for the isolated lens and for the whole eye.
The MTF of the isolated lens obtained under both in vitro and in vivo conditions showed comparable results for both pupil sizes. However, differences were found when comparing the MTF of the whole eye with the lens implanted versus the MTF measured in vitro for 4.5 mm pupil size. Also, the MTFa defocus curve was compared with the defocus curve measured in vivo.
The defocus curve from the in vivo study aligns closely with the MTFa of the in vitro model, with a useful defocus range of 0.40D. Thus, it is possible to anticipate the visual results of the implanted isofocal lens by using measurements on an optical bench and conducting optical simulations.
本研究旨在比较实验室分析（体外）和临床数据（体内）获得的光学质量结果。
使用调制传递函数（MTF）评估 ISOPure 人工晶状体的光学质量，瞳孔直径分别为 3.0 和 4.5mm。体外测量使用 NIMO TRF1504 偏光仪进行，而体内测量则使用 OPD-Scan III 在一组植入该镜片的患者中进行。使用光线追踪技术从测量的波前确定 MTF 和 MTF 曲线下的面积（MTFa），对于孤立的镜片和整个眼睛。
在体外和体内条件下获得的孤立镜片的 MTF 对于两种瞳孔大小均显示出可比的结果。然而，当比较植入整个眼睛的 MTF 与 4.5mm 瞳孔大小的体外测量的 MTF 时，发现了差异。此外，还比较了离焦曲线与体内测量的离焦曲线。
体内研究的离焦曲线与体外模型的 MTFa 非常吻合，有用的离焦范围为 0.40D。因此，通过在光学台上进行测量和进行光学模拟，可以预测植入等焦距晶状体的视觉效果。
