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Is carnitine palmitoyltransferase inhibited by a malonyl-CoA-binding unit in the mitochondria?

作者信息

Bergseth S, Lund H, Bremer J

出版信息

Biochem Soc Trans. 1986 Aug;14(4):671-2. doi: 10.1042/bst0140671.

DOI:10.1042/bst0140671
PMID:3743880
Abstract
摘要

相似文献

1
Is carnitine palmitoyltransferase inhibited by a malonyl-CoA-binding unit in the mitochondria?肉碱棕榈酰转移酶是否受到线粒体中丙二酰辅酶A结合单元的抑制？
Biochem Soc Trans. 1986 Aug;14(4):671-2. doi: 10.1042/bst0140671.
2
Effects of DL-2-bromopalmitoyl-CoA and bromoacetyl-CoA in rat liver and heart mitochondria. Inhibition of carnitine palmitoyltransferase and displacement of [14C]malonyl-CoA from mitochondrial binding sites.DL-2-溴棕榈酰辅酶A和溴乙酰辅酶A对大鼠肝脏和心脏线粒体的影响。对肉碱棕榈酰转移酶的抑制作用以及[14C]丙二酰辅酶A从线粒体结合位点的置换。
Biochem J. 1985 Aug 15;230(1):169-79. doi: 10.1042/bj2300169.
3
Carnitine palmitoyltransferase: separation of enzyme activity and malonyl-CoA binding in rat liver mitochondria.肉碱棕榈酰转移酶：大鼠肝脏线粒体中酶活性与丙二酰辅酶A结合的分离
Biochim Biophys Acta. 1986 Sep 12;878(2):243-9. doi: 10.1016/0005-2760(86)90152-9.
4
Carnitine palmitoyltransferase (CPT2) from liver mitochondrial inner membrane becomes inhibitable by malonyl-CoA if reconstituted with outer membrane malonyl-CoA binding protein.如果用外膜丙二酰辅酶A结合蛋白进行重组，来自肝线粒体内膜的肉碱棕榈酰转移酶（CPT2）会被丙二酰辅酶A抑制。
FEBS Lett. 1990 Sep 3;269(2):406-8. doi: 10.1016/0014-5793(90)81204-2.
5
Effects of fasting and malonyl CoA on the kinetics of carnitine palmitoyltransferase and carnitine octanoyltransferase in intact rat liver mitochondria.禁食和丙二酰辅酶A对完整大鼠肝脏线粒体中肉碱棕榈酰转移酶和肉碱辛酰转移酶动力学的影响。
FEBS Lett. 1981 Sep 28;132(2):166-8. doi: 10.1016/0014-5793(81)81152-0.
6
Interacting effects of L-carnitine and malonyl-CoA on rat liver carnitine palmitoyltransferase.左旋肉碱与丙二酰辅酶A对大鼠肝脏肉碱棕榈酰转移酶的相互作用
Biochem J. 1985 Aug 15;230(1):161-7. doi: 10.1042/bj2300161.
7
Binding of [14C]malonyl-CoA to rat liver mitochondria after blocking of the active site of carnitine palmitoyltransferase I. Displacement of low-affinity binding by palmitoyl-CoA.肉碱棕榈酰转移酶I活性位点被阻断后，[14C]丙二酰辅酶A与大鼠肝脏线粒体的结合。棕榈酰辅酶A对低亲和力结合的置换。
Biochem J. 1986 Jan 15;233(2):589-93. doi: 10.1042/bj2330589.
8
Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro.在体外将完整大鼠肝脏线粒体与微摩尔浓度的丙二酰辅酶A预孵育后，肉碱棕榈酰转移酶I活性对丙二酰辅酶A抑制作用的敏感性增加。
Biochem J. 1983 Mar 15;210(3):953-6. doi: 10.1042/bj2100953.
9
Binding of malonyl-CoA to isolated mitochondria. Evidence for high- and low-affinity sites in liver and heart and relationship to inhibition of carnitine palmitoyltransferase activity.丙二酰辅酶A与分离的线粒体的结合。肝脏和心脏中高亲和力和低亲和力位点的证据及其与肉碱棕榈酰转移酶活性抑制的关系。
Biochem J. 1984 Sep 15;222(3):639-47. doi: 10.1042/bj2220639.
10
Ethanol increases the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in short-term hepatocyte incubations.在短期肝细胞培养中，乙醇会增加肉碱棕榈酰转移酶I对丙二酰辅酶A抑制作用的敏感性。
Biochim Biophys Acta. 1989 Apr 26;1002(3):405-8. doi: 10.1016/0005-2760(89)90358-5.

引用本文的文献

1
Evidence against direct involvement of phosphorylation in the activation of carnitine palmitoyltransferase by okadaic acid in rat hepatocytes.关于大鼠肝细胞中冈田酸通过磷酸化直接参与肉碱棕榈酰转移酶激活的证据不足。
Biochem J. 1994 Jun 15;300 ( Pt 3)(Pt 3):693-9. doi: 10.1042/bj3000693.
2
Intertissue differences in the hysteretic behaviour of carnitine palmitoyltransferase in the presence of malonyl-CoA.在丙二酰辅酶A存在的情况下，肉碱棕榈酰转移酶滞后行为的组织间差异。
Biochem J. 1986 Jul 1;237(1):289-91. doi: 10.1042/bj2370289.
3
Studies on the activation in vitro of carnitine palmitoyltransferase I in liver mitochondria from normal, diabetic and glucagon-treated rats.
正常、糖尿病及胰高血糖素处理大鼠肝脏线粒体中肉碱棕榈酰转移酶I的体外激活研究。
Biochem J. 1987 Apr 1;243(1):261-5. doi: 10.1042/bj2430261.
4
Some differences in the properties of carnitine palmitoyltransferase activities of the mitochondrial outer and inner membranes.线粒体外膜和内膜肉碱棕榈酰转移酶活性在性质上存在一些差异。
Biochem J. 1987 Dec 15;248(3):727-33. doi: 10.1042/bj2480727.