Zhang Yaling, Li Kaiyun, Zhang Chao, Liao Hui, Li Rongshan
Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, People's Republic of China.
Department of Nephrology, Taiyuan Central Hospital, Taiyuan, People's Republic of China.
J Inflamm Res. 2023 Jul 7;16:2817-2830. doi: 10.2147/JIR.S413374. eCollection 2023.
Renal fibrosis is a hallmark and common outcome of various chronic kidney diseases (CKDs) and manifests pathologically as accumulation and deposition of extracellular matrix (ECM) in the kidney. Epithelial-to-mesenchymal transition (EMT) has been shown to be an important mechanism involved in renal fibrosis. , a traditional Chinese medicine, has long been used for the treatment of renal fibrosis. As research on the mycelium of progressed, a variety of medicines developed from fermented mycelium were used to treat CKD. However, their efficacies and mechanisms have not been fully summarized. In this review, five medicines developed from fermented mycelium of are presented. The pharmacodynamic effects of on different animal models of renal fibrosis are summarized. The in vitro studies and related mechanisms of on renal cells are detailed. Finally, the application and efficacy of these five commercial medicines that meet national standards in different types of CKD are summarized. From this review, it can be concluded that can alleviate various causes of renal fibrosis to some extent, and its mechanism is related to TGF-β1 dependent signaling, inhibition of inflammation, and improvement of renal function. Further research on rigorously designed, large-sample, clinically randomized controlled trial studies and detailed mechanisms should be conducted.
肾纤维化是各种慢性肾脏病（CKD）的一个标志和常见结局，其病理表现为细胞外基质（ECM）在肾脏中的积聚和沉积。上皮-间质转化（EMT）已被证明是参与肾纤维化的一个重要机制。[某种中药名称]长期以来一直用于治疗肾纤维化。随着对[该中药名称]菌丝体研究的进展，多种从发酵菌丝体制备的药物被用于治疗CKD。然而，它们的疗效和作用机制尚未得到充分总结。在本综述中，介绍了五种从[该中药名称]发酵菌丝体制备的药物。总结了[该中药名称]对不同肾纤维化动物模型的药效学作用。详细阐述了[该中药名称]对肾细胞的体外研究及相关机制。最后，总结了这五种符合国家标准的商业药物在不同类型CKD中的应用和疗效。从本综述可以得出结论，[该中药名称]可以在一定程度上缓解各种肾纤维化病因，其机制与转化生长因子-β1（TGF-β1）依赖性信号传导、炎症抑制和肾功能改善有关。应开展设计严谨、大样本、临床随机对照试验研究及详细机制的进一步研究。
