Tan Wei, Wang Yunyan, Dai Hongmei, Deng Junhui, Wu Zhifen, Lin Lirong, Yang Jurong
Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Nephrology, YunYang County People's Hospital, Chongqing, China.
Front Pharmacol. 2022 Jul 8;13:932172. doi: 10.3389/fphar.2022.932172. eCollection 2022.
At present, there is no effective drug for the treatment of renal fibrosis; in particular, a safe and effective treatment for renal fibrosis should be established. Cordyceps has several medical effects, including immunoregulatory, antitumor, anti-inflammatory, and antioxidant effects, and may prevent kidney, liver, and heart diseases. Cordyceps has also been reported to be effective in the treatment of renal fibrosis. In this paper, we review the potential mechanisms of Cordyceps against renal fibrosis, focusing on the effects of Cordyceps on inflammation, oxidative stress, apoptosis, regulation of autophagy, reduction of extracellular matrix deposition, and fibroblast activation. We also discuss relevant published clinical trials and meta-analyses. Available clinical studies support the possibility that Cordyceps and related products provide benefits to patients with chronic kidney diseases as adjuvants to conventional drugs. However, the existing clinical studies are limited by low quality and significant heterogeneity. The use of Cordyceps and related products may be a potential strategy for the treatment of renal fibrosis. Randomized controlled trial studies with good methodological quality, favorable experimental design, and large sample size are needed to evaluate the efficacy and safety of Cordyceps.
目前，尚无治疗肾纤维化的有效药物；尤其需要建立一种安全有效的肾纤维化治疗方法。冬虫夏草具有多种医学功效，包括免疫调节、抗肿瘤、抗炎和抗氧化作用，可能预防肾脏、肝脏和心脏疾病。也有报道称冬虫夏草对肾纤维化的治疗有效。在本文中，我们综述了冬虫夏草抗肾纤维化的潜在机制，重点关注冬虫夏草对炎症、氧化应激、细胞凋亡、自噬调节、细胞外基质沉积减少和成纤维细胞活化的影响。我们还讨论了相关已发表的临床试验和荟萃分析。现有的临床研究支持冬虫夏草及相关产品作为传统药物的辅助剂为慢性肾脏病患者带来益处的可能性。然而，现有的临床研究受到质量低和显著异质性的限制。使用冬虫夏草及相关产品可能是治疗肾纤维化的一种潜在策略。需要进行方法学质量好、实验设计合理且样本量较大的随机对照试验研究来评估冬虫夏草的疗效和安全性。
