Friedman Paul M, Jih Ming H, Kimyai-Asadi Arash, Goldberg Leonard H
University of Texas Houston School of Medicine MD Anderson Cancer Center, Houston, Texas, USA.
Dermatol Surg. 2004 Feb;30(2 Pt 1):147-51. doi: 10.1111/j.1524-4725.2004.30062.x.
The 1450-nm diode laser has been found to damage sebaceous glands selectively and to be effective for the treatment of inflammatory acne on the back.
To evaluate the efficacy and safety of the 1450-nm diode laser in the treatment of inflammatory facial acne vulgaris.
Nineteen patients with inflammatory facial acne were treated with the 1450-nm diode laser at 4- to 6-week intervals. There was no control group. Clinical photographs and lesion counts were obtained at baseline and after each treatment. Subjective evaluation of response to treatment and pain was assessed using a questionnaire.
All patients had a reduction in acne lesions. Lesion counts decreased 37% after one treatment (p<0.01), 58% after two treatments (p<0.01), and 83% after three treatments (p<0.01). Treatment-related pain was well tolerated, and adverse effects were limited to transient erythema and edema at treatment sites.
This is the first published report documenting the safety and efficacy of laser treatment for inflammatory facial acne. In our study, clinical improvement was seen in all patients and was generally dramatic, even in those refractory to previous treatment with oral isotretinoin. Topical anesthetics should be used to minimize pain associated with treatment.
已发现1450纳米二极管激光可选择性损伤皮脂腺，对背部炎性痤疮有效。
评估1450纳米二极管激光治疗面部寻常性炎性痤疮的疗效和安全性。
19例面部炎性痤疮患者接受1450纳米二极管激光治疗，间隔4至6周进行一次。未设对照组。在基线及每次治疗后拍摄临床照片并计数皮损数量。使用问卷对治疗反应和疼痛进行主观评估。
所有患者的痤疮皮损均有减少。一次治疗后皮损数量减少37%（p<0.01），两次治疗后减少58%（p<0.01），三次治疗后减少83%（p<0.01）。与治疗相关的疼痛耐受性良好，不良反应仅限于治疗部位的短暂红斑和水肿。
这是首篇发表的记录激光治疗面部炎性痤疮安全性和疗效的报告。在我们的研究中，所有患者均有临床改善，且通常较为显著，即使是那些对先前口服异维A酸治疗无效的患者。应使用局部麻醉剂以减轻与治疗相关的疼痛。
