类moronecidin肽对……和……的抗真菌效力 。 （注：原文中“against”后面内容不完整）
antifungal potency of the moronecidin-like peptide against and .
作者信息
Amirrajab Nasrin, Amin Ayatollahi Mousavi Seyed, Taheri Behrooz, Salari Samira, Sarsahra Noor Ali Ahmadi
机构信息
Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Parasitology and Mycology, School of Medicine, Medical Mycology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Iran J Microbiol. 2023 Jun;15(3):456-461. doi: 10.18502/ijm.v15i3.12907.
BACKGROUND AND OBJECTIVES
The aim of this study was to investigate the antifungal potency of the moronecidin-like peptide against , and
MATERIALS AND METHODS
To evaluate the antifungal effect of moronecidin-like peptide, the protocol presented in CLSI M27-A3 and CLSI M27-S4 was used and the minimum inhibitory concentration was determined.
RESULTS
The minimum inhibitory effect of moronecidin-like peptide composition was 8 µg/ml for and and 32 µg/ml for . The MIC of nystatin was determined to be 1.25 µg/ml for and and 0.625 µg/ml for strains. The MFC composition of the moronecidin-like peptide was determined for and strains 8 µg/ml and for strain 64 µg/ml. The results of cytotoxicity and hemolysis of the moronecidin peptide test on macrophage showed that moronecidin peptide has no cytotoxicity and toxicity properties.
CONCLUSION
According to the results of the present study, the moronecidin-like peptide could be a new strategy in the treatment of infections caused by strains. The discovery of the exact mechanism of which requires extensive clinical studies in this field.
背景与目的
本研究旨在调查类莫罗尼杀菌肽对[具体菌种名称未给出]的抗真菌效力。
材料与方法
为评估类莫罗尼杀菌肽的抗真菌效果，采用了CLSI M27 - A3和CLSI M27 - S4中所述的方案，并测定了最低抑菌浓度。
结果
类莫罗尼杀菌肽组合物对[具体菌种名称未给出]的最低抑菌效果为8μg/ml，对[具体菌种名称未给出]为32μg/ml。制霉菌素对[具体菌种名称未给出]的MIC测定为1.25μg/ml，对[具体菌种名称未给出]菌株为0.625μg/ml。类莫罗尼杀菌肽对[具体菌种名称未给出]和[具体菌种名称未给出]菌株的MFC组合物测定为8μg/ml，对[具体菌种名称未给出]菌株为64μg/ml。类莫罗尼杀菌肽对巨噬细胞的细胞毒性和溶血试验结果表明，类莫罗尼杀菌肽没有细胞毒性和毒性特性。
结论
根据本研究结果，类莫罗尼杀菌肽可能是治疗由[具体菌种名称未给出]菌株引起的感染的一种新策略。其确切机制的发现需要该领域广泛的临床研究。
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