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Newfound physiological function of FAIM protein offers hope of novel disease-modifying therapy for Alzheimer's disease.

作者信息

Balaj Allison R, Kaku Hiroaki

机构信息

Department of Investigative Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA.

出版信息

Neural Regen Res. 2023 Dec;18(12):2677-2679. doi: 10.4103/1673-5374.374003.

DOI:10.4103/1673-5374.374003
PMID:37449619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10358651/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f85d/10358651/917e9a56ffdb/NRR-18-2677-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f85d/10358651/77c0244f13a0/NRR-18-2677-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f85d/10358651/917e9a56ffdb/NRR-18-2677-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f85d/10358651/77c0244f13a0/NRR-18-2677-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f85d/10358651/917e9a56ffdb/NRR-18-2677-g002.jpg

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本文引用的文献

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Nature. 2022 Dec;612(7939):328-337. doi: 10.1038/s41586-022-05491-6. Epub 2022 Nov 30.
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Small Heat Shock Proteins Collaborate with FAIM to Prevent Accumulation of Misfolded Protein Aggregates.小分子热休克蛋白与 FAIM 合作防止错误折叠的蛋白质聚集体的积累。
Int J Mol Sci. 2022 Oct 6;23(19):11841. doi: 10.3390/ijms231911841.
3
Incidence of Amyloid-Related Imaging Abnormalities in Patients With Alzheimer Disease Treated With Anti-β-Amyloid Immunotherapy: A Meta-analysis.
抗β-淀粉样蛋白免疫疗法治疗阿尔茨海默病患者的淀粉样蛋白相关成像异常发生率：一项荟萃分析。
Neurology. 2022 Nov 8;99(19):e2092-e2101. doi: 10.1212/WNL.0000000000201019. Epub 2022 Aug 29.
4
Amyloid-Related Imaging Abnormalities With Anti-amyloid Antibodies for the Treatment of Dementia Due to Alzheimer's Disease.用于治疗阿尔茨海默病所致痴呆的抗淀粉样蛋白抗体相关的影像学异常
Front Neurol. 2022 Mar 23;13:862369. doi: 10.3389/fneur.2022.862369. eCollection 2022.
5
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6
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Prescribing Aducanumab in the Face of Meager Efficacy and Real Risks.在疗效甚微且存在实际风险的情况下开具阿杜卡单抗处方。
Neurology. 2021 Sep 14;97(11):545-547. doi: 10.1212/WNL.0000000000012452. Epub 2021 Jul 7.
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