Nielsen N V
Acta Ophthalmol (Copenh). 1984 Apr;62(2):256-65.
The course of diabetic retinopathy was investigated in 215 out of 227 insulin-treated diabetics in a one year epidemiological cohort study. Twelve diabetics, all with an onset age greater than or equal to 30 years, could not be re-examined due to deaths in 11 diabetics and deny in 1 diabetic. At the one year follow-up no change (P greater than 0.10) occurred in the prevalence of background retinopathy (50.0% vs 51.6%) or of proliferative retinopathy (16.3% vs 18.6%). The one year incidence of newly developed background retinopathy was 3.7% and of deteriorated retinopathy 10.7%. Newly developed proliferative retinopathy was found in 2.3% of the diabetics after one year. Deterioration of pre-existing background retinopathy developed most frequently among diabetics with a diabetes duration above 10 years. Deterioration of both background retinopathy and proliferative retinopathy showed a sudden onset in some diabetics. Partial sight and legal blindness caused by diabetic retinopathy developed in 3.7% of the diabetics, respectively.
在一项为期一年的流行病学队列研究中，对227例接受胰岛素治疗的糖尿病患者中的215例患者的糖尿病视网膜病变病程进行了调查。12例糖尿病患者，均为发病年龄大于或等于30岁，由于11例患者死亡和1例患者拒绝而未能进行复查。在一年的随访中，背景性视网膜病变的患病率（50.0%对51.6%）或增殖性视网膜病变的患病率（16.3%对18.6%）没有变化（P>0.10）。新发生的背景性视网膜病变的一年发病率为3.7%，视网膜病变恶化的发病率为10.7%。一年后，2.3%的糖尿病患者出现了新发生的增殖性视网膜病变。在糖尿病病程超过10年的糖尿病患者中，已存在的背景性视网膜病变恶化最为常见。在一些糖尿病患者中，背景性视网膜病变和增殖性视网膜病变的恶化均表现为突然发作。糖尿病视网膜病变导致的部分视力丧失和法定失明分别发生在3.7%的糖尿病患者中。
