Department of Plastic and Reconstructive Surgery, The Ohio State University Columbus, OH, USA.
Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
J Clin Neurosci. 2023 Sep;115:8-13. doi: 10.1016/j.jocn.2023.07.007. Epub 2023 Jul 14.
Migraine headaches and obesity are both prevalent disorders, resulting in a high socioeconomic burden. To better understand the relationship between obesity and migraine, the aim of this study was to investigate the association between migraine severity, metabolic syndrome and estrogen-associated variables. A retrospective analysis of adult patients with refractory migraine seen by our senior author (J.E.J.) was performed. Patient demographics and migraine characteristics, including migraine intensity, duration, and number of headaches per month were collected from medical records. Migraine headache index (MHI) was calculated by multiplying frequency, intensity and duration of headaches. Weight and height were used to calculate body mass index (BMI) and these were divided per Center for Disease Control (CDC) classifications. Univariate linear regression models were used to evaluate associations. Patients (n = 223) were predominantly female (78%) with a mean age of 44 years at presentation. Patients with a BMI higher than 40 (class 3 obesity) had a higher MHI (p = 0.01) and experienced a higher number of migraines per month (p = 0.007), compared to patients with a healthy BMI, respectively. Migraine frequency was found to be significantly higher in post-menopausal women compared to pre-menopausal women (p = 0.02). No other significant associations were found. This study found that severe obesity (BMI > 40) is associated with increased migraine severity and frequency. Post-menopausal patients are also found to have increased migraine frequency, which could be explained by the estrogen-withdrawal hypothesis. Future studies are needed to evaluate the outcomes of individuals with obesity after nerve deactivation surgery.
偏头痛和肥胖都是常见的疾病，会给社会经济带来沉重负担。为了更好地了解肥胖与偏头痛之间的关系，本研究旨在探讨偏头痛严重程度、代谢综合征与雌激素相关变量之间的关系。对我们的资深作者（J.E.J.）诊治的成年难治性偏头痛患者进行了回顾性分析。从病历中收集了患者的人口统计学和偏头痛特征，包括偏头痛的强度、持续时间和每月头痛的次数。通过将头痛的频率、强度和持续时间相乘来计算偏头痛头痛指数（MHI）。体重和身高用于计算体重指数（BMI），并根据疾病控制与预防中心（CDC）的分类进行划分。使用单变量线性回归模型来评估相关性。患者（n=223）主要为女性（78%），就诊时的平均年龄为 44 岁。与健康体重指数的患者相比，BMI 高于 40（3 级肥胖）的患者 MHI 更高（p=0.01），每月头痛次数更多（p=0.007）。与绝经前女性相比，绝经后女性的偏头痛发作频率明显更高（p=0.02）。未发现其他显著相关性。本研究发现，严重肥胖（BMI>40）与偏头痛严重程度和频率增加有关。绝经后患者也发现偏头痛发作频率增加，这可以用雌激素撤退假说来解释。需要进一步的研究来评估肥胖患者在神经去激活手术后的结果。
