Martini Nafiza, Hawa Tamam, Almouallem Mohamad Moamen, Hanna Majd, Almasri Imad-Addin, Hamzeh Ghassan
Faculty of Medicine, Damascus University, Damascus, Syria.
Medical Research Department, Stemosis for Scientific Research, Damascus, Syria.
Sci Rep. 2025 Feb 3;15(1):4148. doi: 10.1038/s41598-025-87487-6.
This study aimed to investigate the relationship between potential risk factors and migraine among Syrian women through a cross-sectional case-control design. A total of 989 women were enrolled, including 519 migraine patients and 470 non-migraine controls. Data collection involved a comprehensive questionnaire covering demographic information, clinical features, and medical history. Statistical analysis was performed using descriptive statistics and Chi-Square tests. The findings revealed that migraineurs were more likely to smoke, have a higher BMI, have a family history of migraines (particularly in first-degree relatives), have a surgical history, and have undergone a cesarean delivery. No significant associations were found between migraine and allergies, anemia, contraceptive use, or menstrual cycle regularity. These results support existing literature on smoking, BMI, and family history as established risk factors for migraine, while also highlighting the novel associations between migraine and surgical history and delivery type. The study emphasizes the importance of addressing modifiable lifestyle factors and understanding familial predispositions in managing migraine in Syrian women. Further research in this region is crucial for a better understanding of the disease and effective management strategies.
本研究旨在通过横断面病例对照设计，调查叙利亚女性潜在风险因素与偏头痛之间的关系。共纳入989名女性，其中包括519名偏头痛患者和470名非偏头痛对照者。数据收集采用一份涵盖人口统计学信息、临床特征和病史的综合问卷。使用描述性统计和卡方检验进行统计分析。研究结果显示，偏头痛患者更有可能吸烟、BMI较高、有偏头痛家族史（尤其是一级亲属）、有手术史以及接受过剖宫产。在偏头痛与过敏、贫血、避孕措施使用或月经周期规律之间未发现显著关联。这些结果支持了现有关于吸烟、BMI和家族史作为偏头痛既定风险因素的文献，同时也突出了偏头痛与手术史和分娩方式之间的新关联。该研究强调了在管理叙利亚女性偏头痛时，应对可改变的生活方式因素以及了解家族易感性的重要性。在该地区进行进一步研究对于更好地理解该疾病和有效的管理策略至关重要。
