Canada A T, Calabrese E J, Leonard D
J Gerontol. 1986 Sep;41(5):587-9. doi: 10.1093/geronj/41.5.587.
The effect of age on the metabolism of pentobarbital in mice and rats was investigated following exposure to 0.3 ppm of ozone for 3.75 hr. Young animals were 2.5 months of age and the mature were 18 months. The pentobarbital sleeping time was significantly prolonged following the ozone exposure in both the mice and rats when compared with an air control. No ozone effect on sleeping time was found in the young animals. The results indicate that there may be an age-related sensitivity to the occurrence of ozone-related inhibition of pentobarbital metabolism.
在小鼠和大鼠暴露于0.3 ppm臭氧3.75小时后，研究了年龄对戊巴比妥代谢的影响。幼龄动物为2.5月龄，成年动物为18月龄。与空气对照组相比，臭氧暴露后小鼠和大鼠的戊巴比妥睡眠时间均显著延长。在幼龄动物中未发现臭氧对睡眠时间有影响。结果表明，对于臭氧相关的戊巴比妥代谢抑制的发生，可能存在与年龄相关的敏感性。
