Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Biotechnology and Bioinformatics Area, NIIT University, Neemrana, Rajasthan, India.
Cancer Rep (Hoboken). 2023 Nov;6(11):e1870. doi: 10.1002/cnr2.1870. Epub 2023 Jul 17.
Prebiotics is a relatively neglected area in cancer research, despite evidence suggesting that it plays a key role in suppressing tumour growth and improving immune function.
Including prebiotics in the diet has been shown to strengthen the immune system and can better slow down or prevent the growth of tumours. It has also been strongly indicated in various scientific studies that prebiotics can contribute to the sustenance of a healthy microbiome, which in turn plays an important role in increasing the effectiveness and reducing the side effects of cancer treatments.
In the present review article we highlight the mechanisms by which prebiotics like inulin, fructooligosaccharide (FOS), β-glucan, pectin, and xylooligosaccharide (XOS) function. Furthermore, the beneficial effect of incorporating prebiotics during cancer therapy to improvise gut health and prevent/reverse the damage caused to patients due to chemotherapy has also been elaborated.
尽管有证据表明益生元在抑制肿瘤生长和改善免疫功能方面发挥着关键作用，但它在癌症研究中仍是一个相对被忽视的领域。
在饮食中添加益生元已被证明可以增强免疫系统，并能更好地减缓或阻止肿瘤的生长。在各种科学研究中也强烈表明，益生元有助于维持健康的微生物组，而健康的微生物组在提高癌症治疗效果和减少副作用方面起着重要作用。
在本文综述中，我们强调了菊粉、低聚果糖（FOS）、β-葡聚糖、果胶和木低聚糖（XOS）等益生元的作用机制。此外，还阐述了在癌症治疗过程中添加益生元以改善肠道健康并预防/逆转化疗对患者造成的损害的有益效果。
