Klemp P, Staberg B
J Invest Dermatol. 1986 May;86(5):582-4. doi: 10.1111/1523-1747.ep12355231.
Cutaneous and subcutaneous blood flow (CBF, SBF) were studied in non-lesional psoriatic skin (NLS) of 10 patients with only minimal psoriatic skin manifestations, using the local 133Xe washout method. Measurements of the CBF and SBF in the NLS of the patients and 10 normal individuals yielded no statistically significant differences. The results of the present study indicate that the activity of psoriasis can be monitored by the CBF measurements in the NLS, since previously published values for CBF of NLS have shown increasing values with increasing psoriatic activity. The significance of these findings may be more evidence of humoral factors playing a role in the pathogenesis of the disease. The tissue-to-blood partition coefficient for 133Xe was calculated on the basis of biochemical estimations of the relative content of lipids, proteins, and water in skin biopsies from non-lesional skin sites of 8 psoriatic patients. The relative content of lipids, proteins, and water was normal. Thus, the normal 133Xe partition coefficient of 0.7 ml/g should be used for measurements of the CBF in NLS.
采用局部¹³³Xe洗脱法，对10例仅有轻微银屑病皮肤表现的患者的非皮损性银屑病皮肤（NLS）的皮肤和皮下血流（CBF、SBF）进行了研究。对患者和10名正常个体的NLS中的CBF和SBF进行测量，结果无统计学显著差异。本研究结果表明，可通过NLS中的CBF测量来监测银屑病的活动情况，因为先前发表的NLS的CBF值显示，随着银屑病活动的增加，该值也会升高。这些发现的意义可能更多地证明了体液因素在该疾病发病机制中发挥作用。基于对8例银屑病患者非皮损部位皮肤活检中脂质、蛋白质和水的相对含量的生化估计，计算了¹³³Xe的组织-血液分配系数。脂质、蛋白质和水的相对含量正常。因此，在NLS中测量CBF时应使用正常的¹³³Xe分配系数0.7 ml/g。
