Klemp P
J Invest Dermatol. 1985 Mar;84(3):187-90. doi: 10.1111/1523-1747.ep12264802.
The simultaneously recorded disappearance rates of 133Xe from subcutaneous adipose tissue in the crus were studied in 10 patients with psoriasis vulgaris using atraumatic labeling of the tissue in lesional skin (LS) areas and symmetrical, nonlesional skin (NLS) areas. Control experiments were performed bilaterally in 10 younger, healthy subjects. The subcutaneous washout rate constant was significantly higher in LS, 0.79 +/- 0.05 min-1 X 10(2) compared to the washout rate constant of NLS, 0.56 +/- 0.07 min-1. 10(2) (p less than 0.05), or the washout rate constant in the normal subjects, 0.46 +/- 0.17 min-1 X 10(2) (p less than 0.01). The mean washout rate constant in NLS was 25% higher than the mean washout rate constant in the normal subjects. The difference was, however, not statistically significant. Differences in the washout rate constants might be due to abnormal subcutaneous tissue-to-blood partition (lambda) in the LS--and therefore not reflecting the real differences in the subcutaneous blood flow (SBF). The lambda for 133Xe was therefore measured--using a double isotope washout method (133Xe and [131I]antipyrine)--in symmetrical sites of the lateral crus in LS and NLS of 10 patients with psoriasis vulgaris and in 10 legs of normal subjects. In LS the lambda was 4.52 +/- 1.67 ml/g, which was not statistically different from that of NLS, 5.25 +/- 2.19 ml/g (p less than 0.05), nor from that of normal subcutaneous tissue, 4.98 +/- 1.04 ml/g (p less than 0.05). Calculations of the SBF using the obtained lambda values gave a significantly higher SBF in LS, 3.57 +/- 0.23 ml/100 g/min, compared to SBF in the NLS, 2.94 +/- 0.37 ml/100 g/min (p less than 0.05). There was no statistically significant difference between SBF in NLS and SBF in the normal subjects. The increased SBF in LS of psoriatics might be a secondary phenomenon to an increased heat loss in the lesional skin.
在10例寻常型银屑病患者中，采用无创伤性标记病变皮肤（LS）区域和对称的非病变皮肤（NLS）区域的皮下脂肪组织，研究了双侧小腿皮下脂肪组织中133Xe的同步记录消失率。在10名年轻健康受试者中进行了双侧对照实验。LS区域的皮下清除率常数显著高于NLS区域，分别为0.79±0.05 min-1×10(2) 和0.56±0.07 min-1×10(2) （p<0.05），也高于正常受试者的清除率常数0.46±0.17 min-1×10(2) （p<0.01）。NLS区域的平均清除率常数比正常受试者的平均清除率常数高25%。然而，差异无统计学意义。清除率常数的差异可能是由于LS区域皮下组织与血液的分配系数（lambda）异常，因此不能反映皮下血流量（SBF）的实际差异。因此，采用双同位素清除法（133Xe和[131I]安替比林）测量了10例寻常型银屑病患者LS和NLS区域双侧小腿对称部位以及10名正常受试者腿部的133Xe的lambda。LS区域的lambda为4.52±1.67 ml/g，与NLS区域的5.25±2.19 ml/g（p<0.05）以及正常皮下组织的4.98±1.04 ml/g（p<0.05）无统计学差异。利用获得的lambda值计算的SBF显示，LS区域的SBF显著高于NLS区域，分别为3.57±0.23 ml/100 g/min和2.94±0.37 ml/100 g/min（p<0.05）。NLS区域的SBF与正常受试者的SBF之间无统计学差异。银屑病患者LS区域SBF增加可能是病变皮肤热量损失增加的继发现象。
