Klemp P, Staberg B
J Invest Dermatol. 1983 Dec;81(6):503-6. doi: 10.1111/1523-1747.ep12522836.
The disappearance rate of 133Xe was studied in 20 patients with psoriasis vulgaris, using an epicutaneous labeling technique in involved skin lesions or normal-appearing skin of the proximal extensor site of the forearm. Control experiments were performed in 10 normal subjects. Calculations of the cutaneous blood flow (CBF) in psoriatic skin lesions were performed using a tissue-to-blood partition coefficient for 133Xe, lambda c,pso, of 1.2 ml/100 g/min. lambda c,pso was estimated after the relative content of water, lipids, and proteins had been analyzed in psoriatic skin biopsies of 6 patients with untreated psoriasis. The mean relative content of water was markedly reduced to 23.5 +/- 1.5% (SEM), and lipids and proteins were markedly increased to 2.5 +/- 0.7% and 74.0 +/- 2.2, respectively, compared to previously published data for normal skin (water 72.5%, lipids 1%, proteins 26.5%). Mean CBF in untreated psoriatic skin was 63.5 +/- 9.0 ml/100 g/min. This was significantly higher than the mean CBF in 10 normal subjects, 6.3 +/- 0.5 ml/100 g/min (p much less than 0.0001). Mean CBF in normal-appearing skin in patients with psoriasis was 11.0 +/- 1.3 ml/100 g/min. This was significantly higher than CBF in normal subjects (p less than 0.0002).
采用经皮标记技术，在前臂近端伸侧受累皮肤损害处或外观正常的皮肤对20例寻常型银屑病患者进行了¹³³Xe消失率研究。对10名正常受试者进行了对照实验。使用¹³³Xe的组织 - 血液分配系数λc,pso为1.2 ml/100 g/min来计算银屑病皮肤损害处的皮肤血流量（CBF）。在对6例未经治疗的银屑病患者的银屑病皮肤活检组织分析了水、脂质和蛋白质的相对含量后，估算出λc,pso。与先前发表的正常皮肤数据（水72.5%，脂质1%，蛋白质26.5%）相比，水的平均相对含量显著降低至23.5±1.5%（标准误），脂质和蛋白质则分别显著增加至2.5±0.7%和74.0±2.2%。未经治疗的银屑病皮肤的平均CBF为63.5±9.0 ml/100 g/min。这显著高于10名正常受试者的平均CBF，即6.3±0.5 ml/100 g/min（p远小于0.0001）。银屑病患者外观正常皮肤的平均CBF为11.0±1.3 ml/100 g/min。这显著高于正常受试者的CBF（p小于0.0002）。
