Hughes Jennifer L, Trombello Joseph M, Kennard Betsy D, Slater Holli, Rezaeizadeh Afsaneh, Claassen Cynthia, Wakefield Sarah M, Trivedi Madhukar H
Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Center for Depression Research and Clinical Care, Department of Psychiatry and The Peter O'Donnell Jr. Brain Institute and the Department of Psychiatry at the University of Texas Southwestern Medical Center, Dallas, TX, USA.
Contemp Clin Trials Commun. 2023 May 25;33:101151. doi: 10.1016/j.conctc.2023.101151. eCollection 2023 Jun.
Suicide prevention research is a national priority, and national guidance includes the development of suicide risk management protocols (SRMPs) for the assessment and management of suicidal ideation and behavior in research trials. Few published studies describe how researchers develop and implement SRMPs or articulate what constitutes an acceptable and effective SRMP.
The Texas Youth Depression and Suicide Research Network (TX-YDSRN) was developed with the goal of evaluating screening and measurement-based care in Texas youth with depression or suicidality (i.e., suicidal ideation and/or suicidal behavior). The SRMP was developed for TX-YDSRN through a collaborative, iterative process, consistent with a Learning Healthcare System model.
The final SMRP included training, educational resources for research staff, educational resources for research participants, risk assessment and management strategies, and clinical and research oversight.
The TX-YDSRN SRMP is one methodology for addressing youth participant suicide risk. The development and testing of standard methodologies with a focus on participant safety is an important next step to further the field of suicide prevention research.
自杀预防研究是一项国家重点工作，国家指南包括制定自杀风险管理方案（SRMPs），用于在研究试验中评估和管理自杀意念及行为。很少有已发表的研究描述研究人员如何制定和实施SRMPs，或者阐明什么构成可接受且有效的SRMP。
德克萨斯青少年抑郁与自杀研究网络（TX-YDSRN）的建立旨在评估对德克萨斯州有抑郁或自杀倾向（即自杀意念和/或自杀行为）的青少年进行基于筛查和测量的护理。SRMP是通过一个与学习型医疗系统模型一致的协作性迭代过程为TX-YDSRN开发的。
最终的SMRP包括培训、针对研究人员的教育资源、针对研究参与者的教育资源、风险评估和管理策略以及临床和研究监督。
TX-YDSRN SRMP是解决青少年参与者自杀风险的一种方法。重点关注参与者安全的标准方法的开发和测试是推动自杀预防研究领域发展的重要下一步。
