Respiratory Research Unit, Pulmonary Institute, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Pediatric Unit, Pulmonary Institute, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
PLoS One. 2023 Jul 18;18(7):e0284063. doi: 10.1371/journal.pone.0284063. eCollection 2023.
Patients with coronavirus 2019 (COVID-19) and obstructive sleep apnoea (OSA) have a worse prognosis than COVID-19 patients without OSA. This study aimed to examine the relationship between OSA risk and the severity of COVID-19 in patients undiagnosed with OSA. Patients diagnosed with COVID-19 and hospitalized or admitted to a community hotel were recruited for the study after recovery during a clinic check-up visit 6-8 weeks after discharge. At this visit, they answered the Epworth Sleeping Scale (ESS) and Berlin questionnaire. Demographic and clinical details were collected from electronic medical records. OSA risk was observed in 37 of 119 included patients (31.1%). Patients with high OSA risk were male, significantly older, had a higher body mass index (BMI), and had higher rates of hypertension and snoring than patients with low OSA risk. Moreover, OSA risk was associated with COVID-19 severity; 48.6% of patients with high risk for OSA suffered from severe COVID-19 compared to 22% of patients with low risk for OSA (p = 0.007). The duration of hospitalization for patients with a high OSA risk was 10.97±9.43 days, while that for those with a low OSA risk was 4.71±6.86 days (p = 0.001). After adjusting for BMI, age, hypertension, and chronic disease, the odds ratio was 4.3 (95%CI, 1.2-16, p = 0.029). A high OSA risk was associated with severe COVID-19 and longer hospitalization. Thus, we recommend that the Berlin and ESS questionnaires be completed for every COVID-19-infected patient at hospitalization, especially in the presence of comorbidities.
新冠肺炎（COVID-19）合并阻塞性睡眠呼吸暂停（OSA）的患者预后较单纯 COVID-19 患者更差。本研究旨在观察未经诊断的 OSA 患者中 OSA 风险与 COVID-19 严重程度之间的关系。在出院后 6-8 周的门诊检查期间，招募了因 COVID-19 住院或入住社区酒店的患者进行本研究。在此次就诊时，他们回答了 Epworth 睡眠量表（ESS）和柏林问卷。从电子病历中收集了人口统计学和临床详细信息。在 119 名纳入的患者中观察到 37 例（31.1%）存在 OSA 风险。高 OSA 风险患者为男性，年龄显著较大，体重指数（BMI）较高，高血压和打鼾的发生率高于低 OSA 风险患者。此外，OSA 风险与 COVID-19 严重程度相关；48.6%的高 OSA 风险患者患有严重 COVID-19，而低 OSA 风险患者为 22%（p=0.007）。高 OSA 风险患者的住院时间为 10.97±9.43 天，而低 OSA 风险患者为 4.71±6.86 天（p=0.001）。在调整 BMI、年龄、高血压和慢性病后，比值比为 4.3（95%CI，1.2-16，p=0.029）。高 OSA 风险与严重 COVID-19 和住院时间延长有关。因此，我们建议在住院时为每位 COVID-19 感染患者完成柏林和 ESS 问卷，尤其是在存在合并症的情况下。
