过氧化物介导的含硼膦酸三酯中有机磷的释放：一类新型的有机磷前药。
Peroxide-Mediated Release of Organophosphates from Boron-Containing Phosphotriesters: A New Class of Organophosphate Prodrugs.
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.
出版信息
Org Lett. 2023 Jul 28;25(29):5530-5535. doi: 10.1021/acs.orglett.3c02036. Epub 2023 Jul 18.
Abstract
Phosphate mono- and diesters can be liberated efficiently from boryl allyloxy (BAO) and related phosphotriesters by HO. This protocol was applied to the release of a phosphorylated serine derivative and the nucleotide analogue AZT monophosphate. Nucleotide release in the presence of ATP and a kinase provides a diphosphate, demonstrating that this method can be applied to biological processes.
摘要
硼酸烯丙氧基（BAO）和相关膦酸三酯中的单酯和二酯可以通过 HO 有效地释放。该方案应用于释放磷酸丝氨酸衍生物和核苷酸类似物 AZT 单磷酸。在 ATP 和激酶存在下的核苷酸释放提供了二磷酸，证明该方法可应用于生物过程。
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