双功能氧化可裂解链烯基硼酸酯：基于荧光团-猝灭剂对在细胞过氧化物传感中的应用。
Difunctional oxidatively cleavable alkenyl boronates: application to cellular peroxide sensing from a fluorophore-quencher pair.
作者信息
Klootwyk Brittany M, Fleury Grace M, Albright Savannah, Deiters Alexander, Floreancig Paul E
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
出版信息
Chem Commun (Camb). 2025 Feb 18;61(16):3375-3378. doi: 10.1039/d5cc00090d.
Abstract
This manuscript describes the development of difunctional alkenyl boronates that contain an oxidatively releasable cargo and an amine for attaching to groups that can improve physical properties or enhance cellular targeting. The design is applied to a FRET-based system that delivers a selective fluorescence response in oxidatively stressed cells.
摘要
本手稿描述了双官能硼酸烯酯的开发，该硼酸烯酯含有可氧化释放的有效载荷和用于连接可改善物理性质或增强细胞靶向性的基团的胺。该设计应用于基于荧光共振能量转移（FRET）的系统，该系统在氧化应激细胞中产生选择性荧光响应。
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