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Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages.

作者信息

Sturgess Katherine, Yankova Eliza, Vijayabaskar M S, Isobe Tomoya, Rak Justyna, Kucinski Iwo, Barile Melania, Webster Natalie A, Eleftheriou Maria, Hannah Rebecca, Gozdecka Malgorzata, Vassiliou George, Rausch Oliver, Wilson Nicola K, Göttgens Berthold, Tzelepis Konstantinos

机构信息

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AW, UK.

Department of Haematology, University of Cambridge, Cambridge, CB2 0AW, UK.

出版信息

Leukemia. 2023 Oct;37(10):2133-2137. doi: 10.1038/s41375-023-01965-2. Epub 2023 Jul 19.

DOI:10.1038/s41375-023-01965-2
PMID:37464070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10539174/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f2/10539174/d6226ff58aa9/41375_2023_1965_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f2/10539174/57d1a67be7ea/41375_2023_1965_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f2/10539174/d6226ff58aa9/41375_2023_1965_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f2/10539174/57d1a67be7ea/41375_2023_1965_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f2/10539174/d6226ff58aa9/41375_2023_1965_Fig2_HTML.jpg

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IRF7 suppresses hematopoietic regeneration under stress via CXCR4.IRF7 通过 CXCR4 抑制应激下的造血再生。
Stem Cells. 2021 Feb;39(2):183-195. doi: 10.1002/stem.3308. Epub 2020 Dec 9.
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mA Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.mA 修饰可防止造血发育过程中内源性双链 RNA 的形成和有害的固有免疫反应。
RNA结合蛋白对白血病干细胞进化和功能的定向调控。
Hemasphere. 2024 Aug 22;8(8):e116. doi: 10.1002/hem3.116. eCollection 2024 Aug.
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bioRxiv. 2025 Feb 7:2024.03.08.584053. doi: 10.1101/2024.03.08.584053.
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Proteolysis Targeting Chimera Degraders of the METTL3-14 mA-RNA Methyltransferase.METTL3-14 mA-RNA甲基转移酶的蛋白酶靶向嵌合体降解剂
JACS Au. 2024 Feb 12;4(2):713-729. doi: 10.1021/jacsau.4c00040. eCollection 2024 Feb 26.
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Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10.解析关键 RNA 修饰酶的致癌特性：聚焦 NAT10。
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